Anti-MCEE/ GLOD2 functional antibody

Anti-MCEE/ GLOD2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to MCEE/MCEE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1483-Ab-1/ GM-Tg-hg-SE1483-Ab-2Anti-Human MCEE monoclonal antibodyHuman
GM-Tg-rg-SE1483-Ab-1/ GM-Tg-rg-SE1483-Ab-2Anti-Rat MCEE monoclonal antibodyRat
GM-Tg-mg-SE1483-Ab-1/ GM-Tg-mg-SE1483-Ab-2Anti-Mouse MCEE monoclonal antibodyMouse
GM-Tg-cynog-SE1483-Ab-1/ GM-Tg-cynog-SE1483-Ab-2Anti-Cynomolgus/ Rhesus macaque MCEE monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1483-Ab-1/ GM-Tg-felg-SE1483-Ab-2Anti-Feline MCEE monoclonal antibodyFeline
GM-Tg-cang-SE1483-Ab-1/ GM-Tg-cang-SE1483-Ab-2Anti-Canine MCEE monoclonal antibodyCanine
GM-Tg-bovg-SE1483-Ab-1/ GM-Tg-bovg-SE1483-Ab-2Anti-Bovine MCEE monoclonal antibodyBovine
GM-Tg-equg-SE1483-Ab-1/ GM-Tg-equg-SE1483-Ab-2Anti-Equine MCEE monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1483-Ab-1/ GM-Tg-hg-SE1483-Ab-2; GM-Tg-rg-SE1483-Ab-1/ GM-Tg-rg-SE1483-Ab-2;
GM-Tg-mg-SE1483-Ab-1/ GM-Tg-mg-SE1483-Ab-2; GM-Tg-cynog-SE1483-Ab-1/ GM-Tg-cynog-SE1483-Ab-2;
GM-Tg-felg-SE1483-Ab-1/ GM-Tg-felg-SE1483-Ab-2; GM-Tg-cang-SE1483-Ab-1/ GM-Tg-cang-SE1483-Ab-2;
GM-Tg-bovg-SE1483-Ab-1/ GM-Tg-bovg-SE1483-Ab-2; GM-Tg-equg-SE1483-Ab-1/ GM-Tg-equg-SE1483-Ab-2
Products NameAnti-MCEE monoclonal antibody
Formatmab
Target NameMCEE
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MCEE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1483-Ag-1Recombinant multi-species MCEE/ GLOD2 protein


    Target information

    Target IDGM-SE1483
    Target NameMCEE
    Gene ID84693,73724,293829,704094,479018,101085468,508170,100059601
    Gene Symbol and Synonyms1110007A04Rik,GLOD2,MCE,MCEE,MMCE
    Uniprot AccessionQ96PE7,Q2KIZ3
    Uniprot Entry NameMCEE_HUMAN,MCEE_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000124370
    Target ClassificationN/A

    The target: MCEE, gene name: MCEE, also named as GLOD2. The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.