Anti-D2HDH/ D2HGDH/ D2HGD functional antibody

Anti-D2HDH/ D2HGDH/ D2HGD functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to D2HGDH/D2HGDH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1628-Ab-1/ GM-Tg-hg-SE1628-Ab-2Anti-Human D2HGDH monoclonal antibodyHuman
GM-Tg-rg-SE1628-Ab-1/ GM-Tg-rg-SE1628-Ab-2Anti-Rat D2HGDH monoclonal antibodyRat
GM-Tg-mg-SE1628-Ab-1/ GM-Tg-mg-SE1628-Ab-2Anti-Mouse D2HGDH monoclonal antibodyMouse
GM-Tg-cynog-SE1628-Ab-1/ GM-Tg-cynog-SE1628-Ab-2Anti-Cynomolgus/ Rhesus macaque D2HGDH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1628-Ab-1/ GM-Tg-felg-SE1628-Ab-2Anti-Feline D2HGDH monoclonal antibodyFeline
GM-Tg-cang-SE1628-Ab-1/ GM-Tg-cang-SE1628-Ab-2Anti-Canine D2HGDH monoclonal antibodyCanine
GM-Tg-bovg-SE1628-Ab-1/ GM-Tg-bovg-SE1628-Ab-2Anti-Bovine D2HGDH monoclonal antibodyBovine
GM-Tg-equg-SE1628-Ab-1/ GM-Tg-equg-SE1628-Ab-2Anti-Equine D2HGDH monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-SE1628-Ab-1/ GM-Tg-hg-SE1628-Ab-2; GM-Tg-rg-SE1628-Ab-1/ GM-Tg-rg-SE1628-Ab-2;
GM-Tg-mg-SE1628-Ab-1/ GM-Tg-mg-SE1628-Ab-2; GM-Tg-cynog-SE1628-Ab-1/ GM-Tg-cynog-SE1628-Ab-2;
GM-Tg-felg-SE1628-Ab-1/ GM-Tg-felg-SE1628-Ab-2; GM-Tg-cang-SE1628-Ab-1/ GM-Tg-cang-SE1628-Ab-2;
GM-Tg-bovg-SE1628-Ab-1/ GM-Tg-bovg-SE1628-Ab-2; GM-Tg-equg-SE1628-Ab-1/ GM-Tg-equg-SE1628-Ab-2
Products NameAnti-D2HGDH monoclonal antibody
Target NameD2HGDH
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-D2HGDH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

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    Associated products

    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1628-Ag-1Recombinant multi-species D2HDH/ D2HGDH/ D2HGD protein
    ORF Viral VectorpGMAP000017Human 0 Adenovirus plasmid

    Target information

    Target IDGM-SE1628
    Target NameD2HGDH
    Gene ID728294,98314,301624,702028,609641,101098076,533003,100067872
    Gene Symbol and SynonymsD2HGD,D2HGDH,RGD1307976
    Uniprot AccessionQ8N465,P84850,Q1JPD3
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Gene EnsemblENSG00000180902
    Target ClassificationN/A

    The target: D2HGDH, gene name: D2HGDH, also named as D2HGD. This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.