Anti-D2HDH/ D2HGDH/ D2HGD functional antibody

Anti-D2HDH/ D2HGDH/ D2HGD functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to D2HGDH/D2HGDH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1628-Ab-1/ GM-Tg-hg-SE1628-Ab-2Anti-Human D2HGDH monoclonal antibodyHuman
GM-Tg-rg-SE1628-Ab-1/ GM-Tg-rg-SE1628-Ab-2Anti-Rat D2HGDH monoclonal antibodyRat
GM-Tg-mg-SE1628-Ab-1/ GM-Tg-mg-SE1628-Ab-2Anti-Mouse D2HGDH monoclonal antibodyMouse
GM-Tg-cynog-SE1628-Ab-1/ GM-Tg-cynog-SE1628-Ab-2Anti-Cynomolgus/ Rhesus macaque D2HGDH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1628-Ab-1/ GM-Tg-felg-SE1628-Ab-2Anti-Feline D2HGDH monoclonal antibodyFeline
GM-Tg-cang-SE1628-Ab-1/ GM-Tg-cang-SE1628-Ab-2Anti-Canine D2HGDH monoclonal antibodyCanine
GM-Tg-bovg-SE1628-Ab-1/ GM-Tg-bovg-SE1628-Ab-2Anti-Bovine D2HGDH monoclonal antibodyBovine
GM-Tg-equg-SE1628-Ab-1/ GM-Tg-equg-SE1628-Ab-2Anti-Equine D2HGDH monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1628-Ab-1/ GM-Tg-hg-SE1628-Ab-2; GM-Tg-rg-SE1628-Ab-1/ GM-Tg-rg-SE1628-Ab-2;
GM-Tg-mg-SE1628-Ab-1/ GM-Tg-mg-SE1628-Ab-2; GM-Tg-cynog-SE1628-Ab-1/ GM-Tg-cynog-SE1628-Ab-2;
GM-Tg-felg-SE1628-Ab-1/ GM-Tg-felg-SE1628-Ab-2; GM-Tg-cang-SE1628-Ab-1/ GM-Tg-cang-SE1628-Ab-2;
GM-Tg-bovg-SE1628-Ab-1/ GM-Tg-bovg-SE1628-Ab-2; GM-Tg-equg-SE1628-Ab-1/ GM-Tg-equg-SE1628-Ab-2
Products NameAnti-D2HGDH monoclonal antibody
Formatmab
Target NameD2HGDH
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-D2HGDH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1628-Ag-1Recombinant multi-species D2HDH/ D2HGDH/ D2HGD protein
    ORF Viral VectorpGMAP000017Human 0 Adenovirus plasmid


    Target information

    Target IDGM-SE1628
    Target NameD2HGDH
    Gene ID728294,98314,301624,702028,609641,101098076,533003,100067872
    Gene Symbol and SynonymsD2HGD,D2HGDH,RGD1307976
    Uniprot AccessionQ8N465,P84850,Q1JPD3
    Uniprot Entry NameD2HDH_HUMAN,D2HDH_RAT,D2HDH_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000180902
    Target ClassificationN/A

    The target: D2HGDH, gene name: D2HGDH, also named as D2HGD. This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.