Anti-PRKCE monoclonal antibody
Pre-made anti-PRKCE monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PRKCE/PRKCE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T00895-Ab-1/ GM-Tg-hg-T00895-Ab-2 | Anti-Human PRKCE monoclonal antibody | Human |
GM-Tg-rg-T00895-Ab-1/ GM-Tg-rg-T00895-Ab-2 | Anti-Rat PRKCE monoclonal antibody | Rat |
GM-Tg-mg-T00895-Ab-1/ GM-Tg-mg-T00895-Ab-2 | Anti-Mouse PRKCE monoclonal antibody | Mouse |
GM-Tg-cynog-T00895-Ab-1/ GM-Tg-cynog-T00895-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRKCE monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T00895-Ab-1/ GM-Tg-felg-T00895-Ab-2 | Anti-Feline PRKCE monoclonal antibody | Feline |
GM-Tg-cang-T00895-Ab-1/ GM-Tg-cang-T00895-Ab-2 | Anti-Canine PRKCE monoclonal antibody | Canine |
GM-Tg-bovg-T00895-Ab-1/ GM-Tg-bovg-T00895-Ab-2 | Anti-Bovine PRKCE monoclonal antibody | Bovine |
GM-Tg-equg-T00895-Ab-1/ GM-Tg-equg-T00895-Ab-2 | Anti-Equine PRKCE monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T00895-Ab-1/ GM-Tg-hg-T00895-Ab-2; GM-Tg-rg-T00895-Ab-1/ GM-Tg-rg-T00895-Ab-2; GM-Tg-mg-T00895-Ab-1/ GM-Tg-mg-T00895-Ab-2; GM-Tg-cynog-T00895-Ab-1/ GM-Tg-cynog-T00895-Ab-2; GM-Tg-felg-T00895-Ab-1/ GM-Tg-felg-T00895-Ab-2; GM-Tg-cang-T00895-Ab-1/ GM-Tg-cang-T00895-Ab-2; GM-Tg-bovg-T00895-Ab-1/ GM-Tg-bovg-T00895-Ab-2; GM-Tg-equg-T00895-Ab-1/ GM-Tg-equg-T00895-Ab-2 |
Products Name | Anti-PRKCE monoclonal antibody |
Format | mab |
Target Name | PRKCE |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-PRKCE monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T00895-Ag-1 | Recombinant multi-species KPCE/ PRKCE/ PKCE protein |
ORF Viral Vector | vGMLP000766 | human PRKCE Lentivirus particle |
ORF Viral Vector | pGMLP000766 | human PRKCE Lentivirus plasmid |
ORF Viral Vector | pGMAAV000366 | house mouse Prkce AAV plasmid |
ORF Viral Vector | pGMLPm004777 | mouse Prkce Lentivirus plasmid |
ORF Viral Vector | vGMAAV000366 | house mouse Prkce AAV particle |
ORF Viral Vector | vGMLPm004777 | mouse Prkce Lentivirus particle |
Target information
Target ID | GM-T00895 |
Target Name | PRKCE |
Gene ID | 5581,18754,29340,714533,609934,101100958,507041,100053394 |
Gene Symbol and Synonyms | 5830406C15Rik,nPKC-epsilon,PKCE,PKCepsilon,PKC[e],PRKCE |
Uniprot Accession | Q02156,P09216 |
Uniprot Entry Name | KPCE_HUMAN,KPCE_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000171132 |
Target Classification | Kinase |
The target: PRKCE, gene name: PRKCE, also named as PKCE, nPKC-epsilon. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.