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Anti-ADA2C/ ADRA2C/ ADRA2L2 monoclonal antibody
Anti-ADA2C/ ADRA2C/ ADRA2L2 antibody for FACS & in-vivo assay
Go to ADRA2C/ADRA2C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T01777-Ab-1/ GM-Tg-hg-T01777-Ab-2 | Anti-Human ADRA2C monoclonal antibody | Human |
| GM-Tg-rg-T01777-Ab-1/ GM-Tg-rg-T01777-Ab-2 | Anti-Rat ADRA2C monoclonal antibody | Rat |
| GM-Tg-mg-T01777-Ab-1/ GM-Tg-mg-T01777-Ab-2 | Anti-Mouse ADRA2C monoclonal antibody | Mouse |
| GM-Tg-cynog-T01777-Ab-1/ GM-Tg-cynog-T01777-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADRA2C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T01777-Ab-1/ GM-Tg-felg-T01777-Ab-2 | Anti-Feline ADRA2C monoclonal antibody | Feline |
| GM-Tg-cang-T01777-Ab-1/ GM-Tg-cang-T01777-Ab-2 | Anti-Canine ADRA2C monoclonal antibody | Canine |
| GM-Tg-bovg-T01777-Ab-1/ GM-Tg-bovg-T01777-Ab-2 | Anti-Bovine ADRA2C monoclonal antibody | Bovine |
| GM-Tg-equg-T01777-Ab-1/ GM-Tg-equg-T01777-Ab-2 | Anti-Equine ADRA2C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T01777-Ab-1/ GM-Tg-hg-T01777-Ab-2; GM-Tg-rg-T01777-Ab-1/ GM-Tg-rg-T01777-Ab-2; GM-Tg-mg-T01777-Ab-1/ GM-Tg-mg-T01777-Ab-2; GM-Tg-cynog-T01777-Ab-1/ GM-Tg-cynog-T01777-Ab-2; GM-Tg-felg-T01777-Ab-1/ GM-Tg-felg-T01777-Ab-2; GM-Tg-cang-T01777-Ab-1/ GM-Tg-cang-T01777-Ab-2; GM-Tg-bovg-T01777-Ab-1/ GM-Tg-bovg-T01777-Ab-2; GM-Tg-equg-T01777-Ab-1/ GM-Tg-equg-T01777-Ab-2 |
| Products Name | Anti-ADRA2C monoclonal antibody |
| Format | mab |
| Target Name | ADRA2C |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ADRA2C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ADA2C/ ADRA2C/ ADRA2L2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm005297 | mouse Adra2c Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005297 | mouse Adra2c Lentivirus particle |
Target information
| Target ID | GM-T01777 |
| Target Name | ADRA2C |
| Gene ID | 152,11553,24175,719763,488793,101087990,407139,111772982 |
| Gene Symbol and Synonyms | Adra-2c,ADRA2C,ADRA2L2,ADRA2RL2,ADRARL2,alpha2-C4,alpha2C,ALPHA2CAR,[a]2C |
| Uniprot Accession | P18825,P22086 |
| Uniprot Entry Name | ADA2C_HUMAN,ADA2C_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000184160 |
| Target Classification | GPCR |
The target: ADRA2C, gene name: ADRA2C, also named as ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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