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Anti-ARSB/ G4S/ ASB functional antibody
Anti-ARSB/ G4S/ ASB functional antibody for cell culture, ELISA & in-vivo assay
Go to G4S/ARSB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02119-Ab-1/ GM-Tg-hg-T02119-Ab-2 | Anti-Human G4S/ARSB monoclonal antibody | Human |
| GM-Tg-rg-T02119-Ab-1/ GM-Tg-rg-T02119-Ab-2 | Anti-Rat G4S/ARSB monoclonal antibody | Rat |
| GM-Tg-mg-T02119-Ab-1/ GM-Tg-mg-T02119-Ab-2 | Anti-Mouse G4S/ARSB monoclonal antibody | Mouse |
| GM-Tg-cynog-T02119-Ab-1/ GM-Tg-cynog-T02119-Ab-2 | Anti-Cynomolgus/ Rhesus macaque G4S/ARSB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02119-Ab-1/ GM-Tg-felg-T02119-Ab-2 | Anti-Feline G4S/ARSB monoclonal antibody | Feline |
| GM-Tg-cang-T02119-Ab-1/ GM-Tg-cang-T02119-Ab-2 | Anti-Canine G4S/ARSB monoclonal antibody | Canine |
| GM-Tg-bovg-T02119-Ab-1/ GM-Tg-bovg-T02119-Ab-2 | Anti-Bovine G4S/ARSB monoclonal antibody | Bovine |
| GM-Tg-equg-T02119-Ab-1/ GM-Tg-equg-T02119-Ab-2 | Anti-Equine G4S/ARSB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02119-Ab-1/ GM-Tg-hg-T02119-Ab-2; GM-Tg-rg-T02119-Ab-1/ GM-Tg-rg-T02119-Ab-2; GM-Tg-mg-T02119-Ab-1/ GM-Tg-mg-T02119-Ab-2; GM-Tg-cynog-T02119-Ab-1/ GM-Tg-cynog-T02119-Ab-2; GM-Tg-felg-T02119-Ab-1/ GM-Tg-felg-T02119-Ab-2; GM-Tg-cang-T02119-Ab-1/ GM-Tg-cang-T02119-Ab-2; GM-Tg-bovg-T02119-Ab-1/ GM-Tg-bovg-T02119-Ab-2; GM-Tg-equg-T02119-Ab-1/ GM-Tg-equg-T02119-Ab-2 |
| Products Name | Anti-G4S/ARSB monoclonal antibody |
| Format | mab |
| Target Name | G4S |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-G4S benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T02119-Ag-1 | Recombinant multi-species ARSB/ G4S/ ASB protein |
Target information
| Target ID | GM-T02119 |
| Target Name | G4S |
| Gene ID | 411,11881,25227,709136,610364,100216331,538401,100073268 |
| Gene Symbol and Synonyms | 1110007C02Rik,ARSB,As-1,As-1r,As-1s,As-1t,As1,As1-r,As1-s,As1-t,ASB,Asr-1,Ast-1,G4S,MPS6 |
| Uniprot Accession | P15848,P50430,P33727 |
| Uniprot Entry Name | ARSB_HUMAN,ARSB_RAT,ARSB_FELCA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000113273 |
| Target Classification | N/A |
The target: G4S, gene name: ARSB, also named as ASB, G4S, MPS6. Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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