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Anti-IL4RA/ IL4R/ CD124 monoclonal antibody
Anti-IL4RA/ IL4R/ CD124 antibody for FACS & in-vivo assay
Go to IL4R/IL4R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T03346-Ab-1/ GM-Tg-hg-T03346-Ab-2 | Anti-Human IL4R monoclonal antibody | Human |
| GM-Tg-rg-T03346-Ab-1/ GM-Tg-rg-T03346-Ab-2 | Anti-Rat IL4R monoclonal antibody | Rat |
| GM-Tg-mg-T03346-Ab-1/ GM-Tg-mg-T03346-Ab-2 | Anti-Mouse IL4R monoclonal antibody | Mouse |
| GM-Tg-cynog-T03346-Ab-1/ GM-Tg-cynog-T03346-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL4R monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T03346-Ab-1/ GM-Tg-felg-T03346-Ab-2 | Anti-Feline IL4R monoclonal antibody | Feline |
| GM-Tg-cang-T03346-Ab-1/ GM-Tg-cang-T03346-Ab-2 | Anti-Canine IL4R monoclonal antibody | Canine |
| GM-Tg-bovg-T03346-Ab-1/ GM-Tg-bovg-T03346-Ab-2 | Anti-Bovine IL4R monoclonal antibody | Bovine |
| GM-Tg-equg-T03346-Ab-1/ GM-Tg-equg-T03346-Ab-2 | Anti-Equine IL4R monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T03346-Ab-1/ GM-Tg-hg-T03346-Ab-2; GM-Tg-rg-T03346-Ab-1/ GM-Tg-rg-T03346-Ab-2; GM-Tg-mg-T03346-Ab-1/ GM-Tg-mg-T03346-Ab-2; GM-Tg-cynog-T03346-Ab-1/ GM-Tg-cynog-T03346-Ab-2; GM-Tg-felg-T03346-Ab-1/ GM-Tg-felg-T03346-Ab-2; GM-Tg-cang-T03346-Ab-1/ GM-Tg-cang-T03346-Ab-2; GM-Tg-bovg-T03346-Ab-1/ GM-Tg-bovg-T03346-Ab-2; GM-Tg-equg-T03346-Ab-1/ GM-Tg-equg-T03346-Ab-2 |
| Products Name | Anti-IL4R monoclonal antibody |
| Format | mab |
| Target Name | IL4R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL4R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-680 | Pre-Made Manfidokimab biosimilar, Whole mAb, Anti-IL4R Antibody: Anti-CD124 therapeutic antibody |
| Biosimilar | GMP-Bios-ab-158 | Pre-Made Dupilumab biosimilar, Whole mAb, Anti-IL4R Antibody: Anti-CD124 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species IL4RA/ IL4R/ CD124 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T03346 |
| Target Name | IL4R |
| Gene ID | 3566,16190,25084,705404,489957,101096277,404154,791252 |
| Gene Symbol and Synonyms | CD124,IL-4RA,IL4R,IL4RA |
| Uniprot Accession | P24394,Q63257,Q6WG24 |
| Uniprot Entry Name | IL4RA_HUMAN,IL4RA_RAT,IL4RA_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | atopic asthma |
| Gene Ensembl | ENSG00000077238 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL4R, gene name: IL4R, also named as CD124, IL-4RAA, IL4R. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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