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Anti-LTA4H monoclonal antibody
Pre-made anti-LTA4H monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to LTA4H/LTA4H products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T03691-Ab-1/ GM-Tg-hg-T03691-Ab-2 | Anti-Human LTA4H monoclonal antibody | Human |
| GM-Tg-rg-T03691-Ab-1/ GM-Tg-rg-T03691-Ab-2 | Anti-Rat LTA4H monoclonal antibody | Rat |
| GM-Tg-mg-T03691-Ab-1/ GM-Tg-mg-T03691-Ab-2 | Anti-Mouse LTA4H monoclonal antibody | Mouse |
| GM-Tg-cynog-T03691-Ab-1/ GM-Tg-cynog-T03691-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LTA4H monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T03691-Ab-1/ GM-Tg-felg-T03691-Ab-2 | Anti-Feline LTA4H monoclonal antibody | Feline |
| GM-Tg-cang-T03691-Ab-1/ GM-Tg-cang-T03691-Ab-2 | Anti-Canine LTA4H monoclonal antibody | Canine |
| GM-Tg-bovg-T03691-Ab-1/ GM-Tg-bovg-T03691-Ab-2 | Anti-Bovine LTA4H monoclonal antibody | Bovine |
| GM-Tg-equg-T03691-Ab-1/ GM-Tg-equg-T03691-Ab-2 | Anti-Equine LTA4H monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T03691-Ab-1/ GM-Tg-hg-T03691-Ab-2; GM-Tg-rg-T03691-Ab-1/ GM-Tg-rg-T03691-Ab-2; GM-Tg-mg-T03691-Ab-1/ GM-Tg-mg-T03691-Ab-2; GM-Tg-cynog-T03691-Ab-1/ GM-Tg-cynog-T03691-Ab-2; GM-Tg-felg-T03691-Ab-1/ GM-Tg-felg-T03691-Ab-2; GM-Tg-cang-T03691-Ab-1/ GM-Tg-cang-T03691-Ab-2; GM-Tg-bovg-T03691-Ab-1/ GM-Tg-bovg-T03691-Ab-2; GM-Tg-equg-T03691-Ab-1/ GM-Tg-equg-T03691-Ab-2 |
| Products Name | Anti-LTA4H monoclonal antibody |
| Format | mab |
| Target Name | LTA4H |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-LTA4H monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T03691-Ag-1 | Recombinant multi-species LKHA4/ LTA4H protein |
| ORF Viral Vector | pGMLPm003430 | mouse Lta4h Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003430 | mouse Lta4h Lentivirus particle |
Target information
| Target ID | GM-T03691 |
| Target Name | LTA4H |
| Gene ID | 4048,16993,299732,713038,482611,101083948,507130,100052257 |
| Gene Symbol and Synonyms | LTA4H |
| Uniprot Accession | P09960,P30349,Q3SZH7 |
| Uniprot Entry Name | LKHA4_HUMAN,LKHA4_RAT,LKHA4_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000111144 |
| Target Classification | N/A |
The target: LTA4H, gene name: LTA4H, also named as . The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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