Anti-GASR/ CCKBR/ CCK-B monoclonal antibody
Anti-GASR/ CCKBR/ CCK-B antibody for FACS & in-vivo assay
Go to CCKBR/CCKBR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T05849-Ab-1/ GM-Tg-hg-T05849-Ab-2 | Anti-Human CCKBR monoclonal antibody | Human |
GM-Tg-rg-T05849-Ab-1/ GM-Tg-rg-T05849-Ab-2 | Anti-Rat CCKBR monoclonal antibody | Rat |
GM-Tg-mg-T05849-Ab-1/ GM-Tg-mg-T05849-Ab-2 | Anti-Mouse CCKBR monoclonal antibody | Mouse |
GM-Tg-cynog-T05849-Ab-1/ GM-Tg-cynog-T05849-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCKBR monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T05849-Ab-1/ GM-Tg-felg-T05849-Ab-2 | Anti-Feline CCKBR monoclonal antibody | Feline |
GM-Tg-cang-T05849-Ab-1/ GM-Tg-cang-T05849-Ab-2 | Anti-Canine CCKBR monoclonal antibody | Canine |
GM-Tg-bovg-T05849-Ab-1/ GM-Tg-bovg-T05849-Ab-2 | Anti-Bovine CCKBR monoclonal antibody | Bovine |
GM-Tg-equg-T05849-Ab-1/ GM-Tg-equg-T05849-Ab-2 | Anti-Equine CCKBR monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T05849-Ab-1/ GM-Tg-hg-T05849-Ab-2; GM-Tg-rg-T05849-Ab-1/ GM-Tg-rg-T05849-Ab-2; GM-Tg-mg-T05849-Ab-1/ GM-Tg-mg-T05849-Ab-2; GM-Tg-cynog-T05849-Ab-1/ GM-Tg-cynog-T05849-Ab-2; GM-Tg-felg-T05849-Ab-1/ GM-Tg-felg-T05849-Ab-2; GM-Tg-cang-T05849-Ab-1/ GM-Tg-cang-T05849-Ab-2; GM-Tg-bovg-T05849-Ab-1/ GM-Tg-bovg-T05849-Ab-2; GM-Tg-equg-T05849-Ab-1/ GM-Tg-equg-T05849-Ab-2 |
Products Name | Anti-CCKBR monoclonal antibody |
Format | mab |
Target Name | CCKBR |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CCKBR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species GASR/ CCKBR/ CCK-B VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLP004002 | human CCKBR Lentivirus plasmid |
ORF Viral Vector | vGMLP004002 | human CCKBR Lentivirus particle |
ORF Viral Vector | pGMAP000136 | Human CCKBR Adenovirus plasmid |
ORF Viral Vector | vGMAP000136 | Human CCKBR Adenovirus particle |
Target information
Target ID | GM-T05849 |
Target Name | CCKBR |
Gene ID | 887,12426,25706,712939,485333,101098743,281665,100055073 |
Gene Symbol and Synonyms | CCK-B,CCK-BR,CCK2-R,CCK2R,CCKBR,CCKR-2,Cholrec,GASR |
Uniprot Accession | P32239,P30553,P30552,P79266 |
Uniprot Entry Name | GASR_HUMAN,GASR_RAT,GASR_CANLF,GASR_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000110148 |
Target Classification | Tumor-associated antigen (TAA) |
The target: CCKBR, gene name: CCKBR, also named as CCK-B, CCK2R, GASR. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.