- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-GASR/ CCKBR/ CCK-B monoclonal antibody
Anti-GASR/ CCKBR/ CCK-B antibody for FACS & in-vivo assay
Go to CCKBR/CCKBR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T05849-Ab-1/ GM-Tg-hg-T05849-Ab-2 | Anti-Human CCKBR monoclonal antibody | Human |
| GM-Tg-rg-T05849-Ab-1/ GM-Tg-rg-T05849-Ab-2 | Anti-Rat CCKBR monoclonal antibody | Rat |
| GM-Tg-mg-T05849-Ab-1/ GM-Tg-mg-T05849-Ab-2 | Anti-Mouse CCKBR monoclonal antibody | Mouse |
| GM-Tg-cynog-T05849-Ab-1/ GM-Tg-cynog-T05849-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCKBR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T05849-Ab-1/ GM-Tg-felg-T05849-Ab-2 | Anti-Feline CCKBR monoclonal antibody | Feline |
| GM-Tg-cang-T05849-Ab-1/ GM-Tg-cang-T05849-Ab-2 | Anti-Canine CCKBR monoclonal antibody | Canine |
| GM-Tg-bovg-T05849-Ab-1/ GM-Tg-bovg-T05849-Ab-2 | Anti-Bovine CCKBR monoclonal antibody | Bovine |
| GM-Tg-equg-T05849-Ab-1/ GM-Tg-equg-T05849-Ab-2 | Anti-Equine CCKBR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T05849-Ab-1/ GM-Tg-hg-T05849-Ab-2; GM-Tg-rg-T05849-Ab-1/ GM-Tg-rg-T05849-Ab-2; GM-Tg-mg-T05849-Ab-1/ GM-Tg-mg-T05849-Ab-2; GM-Tg-cynog-T05849-Ab-1/ GM-Tg-cynog-T05849-Ab-2; GM-Tg-felg-T05849-Ab-1/ GM-Tg-felg-T05849-Ab-2; GM-Tg-cang-T05849-Ab-1/ GM-Tg-cang-T05849-Ab-2; GM-Tg-bovg-T05849-Ab-1/ GM-Tg-bovg-T05849-Ab-2; GM-Tg-equg-T05849-Ab-1/ GM-Tg-equg-T05849-Ab-2 |
| Products Name | Anti-CCKBR monoclonal antibody |
| Format | mab |
| Target Name | CCKBR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCKBR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GASR/ CCKBR/ CCK-B VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004002 | human CCKBR Lentivirus plasmid |
| ORF Viral Vector | vGMLP004002 | human CCKBR Lentivirus particle |
| ORF Viral Vector | pGMAP000136 | Human CCKBR Adenovirus plasmid |
| ORF Viral Vector | vGMAP000136 | Human CCKBR Adenovirus particle |
Target information
| Target ID | GM-T05849 |
| Target Name | CCKBR |
| Gene ID | 887,12426,25706,712939,485333,101098743,281665,100055073 |
| Gene Symbol and Synonyms | CCK-B,CCK-BR,CCK2-R,CCK2R,CCKBR,CCKR-2,Cholrec,GASR |
| Uniprot Accession | P32239,P30553,P30552,P79266 |
| Uniprot Entry Name | GASR_HUMAN,GASR_RAT,GASR_CANLF,GASR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000110148 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CCKBR, gene name: CCKBR, also named as CCK-B, CCK2R, GASR. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
