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Anti-CCR4/ CC-CKR-4/ CD194 monoclonal antibody
Anti-CCR4/ CC-CKR-4/ CD194 antibody for FACS & in-vivo assay
Go to CCR4/CCR4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T06955-Ab-1/ GM-Tg-hg-T06955-Ab-2 | Anti-Human CCR4 monoclonal antibody | Human |
| GM-Tg-rg-T06955-Ab-1/ GM-Tg-rg-T06955-Ab-2 | Anti-Rat CCR4 monoclonal antibody | Rat |
| GM-Tg-mg-T06955-Ab-1/ GM-Tg-mg-T06955-Ab-2 | Anti-Mouse CCR4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T06955-Ab-1/ GM-Tg-cynog-T06955-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCR4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T06955-Ab-1/ GM-Tg-felg-T06955-Ab-2 | Anti-Feline CCR4 monoclonal antibody | Feline |
| GM-Tg-cang-T06955-Ab-1/ GM-Tg-cang-T06955-Ab-2 | Anti-Canine CCR4 monoclonal antibody | Canine |
| GM-Tg-bovg-T06955-Ab-1/ GM-Tg-bovg-T06955-Ab-2 | Anti-Bovine CCR4 monoclonal antibody | Bovine |
| GM-Tg-equg-T06955-Ab-1/ GM-Tg-equg-T06955-Ab-2 | Anti-Equine CCR4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T06955-Ab-1/ GM-Tg-hg-T06955-Ab-2; GM-Tg-rg-T06955-Ab-1/ GM-Tg-rg-T06955-Ab-2; GM-Tg-mg-T06955-Ab-1/ GM-Tg-mg-T06955-Ab-2; GM-Tg-cynog-T06955-Ab-1/ GM-Tg-cynog-T06955-Ab-2; GM-Tg-felg-T06955-Ab-1/ GM-Tg-felg-T06955-Ab-2; GM-Tg-cang-T06955-Ab-1/ GM-Tg-cang-T06955-Ab-2; GM-Tg-bovg-T06955-Ab-1/ GM-Tg-bovg-T06955-Ab-2; GM-Tg-equg-T06955-Ab-1/ GM-Tg-equg-T06955-Ab-2 |
| Products Name | Anti-CCR4 monoclonal antibody |
| Format | mab |
| Target Name | CCR4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCR4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-354 | Pre-Made Mogamulizumab biosimilar, Whole mAb, Anti-CCR4 Antibody: Anti-CKR4/K5-5/CD194/CMKBR4/ChemR13/CC-CKR-4/HGCN:14099 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species CCR4/ CC-CKR-4/ CD194 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T06955-Ag-1 | chemokine (C-C motif) receptor 4 (CCR4) protein |
| ORF Viral Vector | vGMLP002020 | human CCR4 Lentivirus particle |
| ORF Viral Vector | pGMLP002020 | human CCR4 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000154 | mouse Ccr4 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000154 | mouse Ccr4 Lentivirus particle |
Target information
| Target ID | GM-T06955 |
| Target Name | CCR4 |
| Gene ID | 1233,12773,171054,705457,403541,102900629,408019,100056549 |
| Gene Symbol and Synonyms | C-C CKR-4,CC-CKR-4,CCR4,CD194,CHEMR1,ChemR13,CKR4,CMKBR4,HGCN:14099,K5-5,LESTR,Sdf1r |
| Uniprot Accession | P51679,Q8MJW8 |
| Uniprot Entry Name | CCR4_HUMAN,CCR4_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000183813 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA) |
The target: CCR4, gene name: CCR4, also named as CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5. The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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