Anti-HPD monoclonal antibody

Pre-made anti-HPD monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to HPD/HPD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T07137-Ab-1/ GM-Tg-hg-T07137-Ab-2Anti-Human HPD monoclonal antibodyHuman
GM-Tg-rg-T07137-Ab-1/ GM-Tg-rg-T07137-Ab-2Anti-Rat HPD monoclonal antibodyRat
GM-Tg-mg-T07137-Ab-1/ GM-Tg-mg-T07137-Ab-2Anti-Mouse HPD monoclonal antibodyMouse
GM-Tg-cynog-T07137-Ab-1/ GM-Tg-cynog-T07137-Ab-2Anti-Cynomolgus/ Rhesus macaque HPD monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T07137-Ab-1/ GM-Tg-felg-T07137-Ab-2Anti-Feline HPD monoclonal antibodyFeline
GM-Tg-cang-T07137-Ab-1/ GM-Tg-cang-T07137-Ab-2Anti-Canine HPD monoclonal antibodyCanine
GM-Tg-bovg-T07137-Ab-1/ GM-Tg-bovg-T07137-Ab-2Anti-Bovine HPD monoclonal antibodyBovine
GM-Tg-equg-T07137-Ab-1/ GM-Tg-equg-T07137-Ab-2Anti-Equine HPD monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T07137-Ab-1/ GM-Tg-hg-T07137-Ab-2; GM-Tg-rg-T07137-Ab-1/ GM-Tg-rg-T07137-Ab-2;
GM-Tg-mg-T07137-Ab-1/ GM-Tg-mg-T07137-Ab-2; GM-Tg-cynog-T07137-Ab-1/ GM-Tg-cynog-T07137-Ab-2;
GM-Tg-felg-T07137-Ab-1/ GM-Tg-felg-T07137-Ab-2; GM-Tg-cang-T07137-Ab-1/ GM-Tg-cang-T07137-Ab-2;
GM-Tg-bovg-T07137-Ab-1/ GM-Tg-bovg-T07137-Ab-2; GM-Tg-equg-T07137-Ab-1/ GM-Tg-equg-T07137-Ab-2
Products NameAnti-HPD monoclonal antibody
Formatmab
Target NameHPD
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-HPD monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T07137-Ag-1Recombinant multi-species HPPD/ HPD/ 4-HPPD protein
    ORF Viral VectorvGMLP002118human HPD Lentivirus particle
    ORF Viral VectorpGMLP002118human HPD Lentivirus plasmid
    ORF Viral VectorpGMAAV000370house mouse Hpd AAV plasmid
    ORF Viral VectorpGMLPm001505mouse Hpd Lentivirus plasmid
    ORF Viral VectorvGMAAV000370house mouse Hpd AAV particle
    ORF Viral VectorvGMLPm001505mouse Hpd Lentivirus particle


    Target information

    Target IDGM-T07137
    Target NameHPD
    Gene ID3242,15445,29531,700940,610778,101093465,516058,100059853
    Gene Symbol and Synonyms4-HPPD,4HPPD,Fla,Flp,GLOD3,HPD,Hppd,HPPDASE,Laf,PPD
    Uniprot AccessionP32754,P32755,Q5EA20
    Uniprot Entry NameHPPD_HUMAN,HPPD_RAT,HPPD_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseProstate Cancer
    Gene EnsemblENSG00000158104
    Target ClassificationN/A

    The target: HPD, gene name: HPD, also named as 4-HPPD, 4HPPD, GLOD3, HPPDASE, PPD. The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.