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Anti-5HT1B/ HTR1B/ 5-HT-1B monoclonal antibody
Anti-5HT1B/ HTR1B/ 5-HT-1B antibody for FACS & in-vivo assay
Go to HTR1B/HTR1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T07806-Ab-1/ GM-Tg-hg-T07806-Ab-2 | Anti-Human HTR1B monoclonal antibody | Human |
| GM-Tg-rg-T07806-Ab-1/ GM-Tg-rg-T07806-Ab-2 | Anti-Rat HTR1B monoclonal antibody | Rat |
| GM-Tg-mg-T07806-Ab-1/ GM-Tg-mg-T07806-Ab-2 | Anti-Mouse HTR1B monoclonal antibody | Mouse |
| GM-Tg-cynog-T07806-Ab-1/ GM-Tg-cynog-T07806-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTR1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T07806-Ab-1/ GM-Tg-felg-T07806-Ab-2 | Anti-Feline HTR1B monoclonal antibody | Feline |
| GM-Tg-cang-T07806-Ab-1/ GM-Tg-cang-T07806-Ab-2 | Anti-Canine HTR1B monoclonal antibody | Canine |
| GM-Tg-bovg-T07806-Ab-1/ GM-Tg-bovg-T07806-Ab-2 | Anti-Bovine HTR1B monoclonal antibody | Bovine |
| GM-Tg-equg-T07806-Ab-1/ GM-Tg-equg-T07806-Ab-2 | Anti-Equine HTR1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T07806-Ab-1/ GM-Tg-hg-T07806-Ab-2; GM-Tg-rg-T07806-Ab-1/ GM-Tg-rg-T07806-Ab-2; GM-Tg-mg-T07806-Ab-1/ GM-Tg-mg-T07806-Ab-2; GM-Tg-cynog-T07806-Ab-1/ GM-Tg-cynog-T07806-Ab-2; GM-Tg-felg-T07806-Ab-1/ GM-Tg-felg-T07806-Ab-2; GM-Tg-cang-T07806-Ab-1/ GM-Tg-cang-T07806-Ab-2; GM-Tg-bovg-T07806-Ab-1/ GM-Tg-bovg-T07806-Ab-2; GM-Tg-equg-T07806-Ab-1/ GM-Tg-equg-T07806-Ab-2 |
| Products Name | Anti-HTR1B monoclonal antibody |
| Format | mab |
| Target Name | HTR1B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HTR1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species 5HT1B/ HTR1B/ 5-HT-1B VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002949 | human HTR1B Lentivirus plasmid |
| ORF Viral Vector | vGMLP002949 | human HTR1B Lentivirus particle |
| ORF Viral Vector | pGMLPm002990 | mouse Htr1b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002990 | mouse Htr1b Lentivirus particle |
Target information
| Target ID | GM-T07806 |
| Target Name | HTR1B |
| Gene ID | 3351,15551,25075,716704,403741,100144391,317707,100009680 |
| Gene Symbol and Synonyms | 5-HT-1B,5-HT-1D-beta,5-HT1B,5-HT1DB,HTR1B,HTR1D2,HTR1DB,S12 |
| Uniprot Accession | P28222,P28564,P79250,Q588Y6,Q0EAB5 |
| Uniprot Entry Name | 5HT1B_HUMAN,5HT1B_RAT,5HT1B_FELCA,5HT1B_CANLF,5HT1B_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Schizophrenia, Alcoholism and substance abuse |
| Gene Ensembl | ENSG00000135312 |
| Target Classification | GPCR |
The target: HTR1B, gene name: HTR1B, also named as 5-HT-1B, 5-HT-1D-beta, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12. The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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