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Anti-ACACB/ ACC2/ ACCB functional antibody
Anti-ACACB/ ACC2/ ACCB functional antibody for cell culture, ELISA & in-vivo assay
Go to ACACB/ACACB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T08922-Ab-1/ GM-Tg-hg-T08922-Ab-2 | Anti-Human ACACB monoclonal antibody | Human |
| GM-Tg-rg-T08922-Ab-1/ GM-Tg-rg-T08922-Ab-2 | Anti-Rat ACACB monoclonal antibody | Rat |
| GM-Tg-mg-T08922-Ab-1/ GM-Tg-mg-T08922-Ab-2 | Anti-Mouse ACACB monoclonal antibody | Mouse |
| GM-Tg-cynog-T08922-Ab-1/ GM-Tg-cynog-T08922-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACACB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T08922-Ab-1/ GM-Tg-felg-T08922-Ab-2 | Anti-Feline ACACB monoclonal antibody | Feline |
| GM-Tg-cang-T08922-Ab-1/ GM-Tg-cang-T08922-Ab-2 | Anti-Canine ACACB monoclonal antibody | Canine |
| GM-Tg-bovg-T08922-Ab-1/ GM-Tg-bovg-T08922-Ab-2 | Anti-Bovine ACACB monoclonal antibody | Bovine |
| GM-Tg-equg-T08922-Ab-1/ GM-Tg-equg-T08922-Ab-2 | Anti-Equine ACACB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T08922-Ab-1/ GM-Tg-hg-T08922-Ab-2; GM-Tg-rg-T08922-Ab-1/ GM-Tg-rg-T08922-Ab-2; GM-Tg-mg-T08922-Ab-1/ GM-Tg-mg-T08922-Ab-2; GM-Tg-cynog-T08922-Ab-1/ GM-Tg-cynog-T08922-Ab-2; GM-Tg-felg-T08922-Ab-1/ GM-Tg-felg-T08922-Ab-2; GM-Tg-cang-T08922-Ab-1/ GM-Tg-cang-T08922-Ab-2; GM-Tg-bovg-T08922-Ab-1/ GM-Tg-bovg-T08922-Ab-2; GM-Tg-equg-T08922-Ab-1/ GM-Tg-equg-T08922-Ab-2 |
| Products Name | Anti-ACACB monoclonal antibody |
| Format | mab |
| Target Name | ACACB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACACB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T08922-Ag-1 | Recombinant multi-species ACACB/ ACC2/ ACCB protein |
Target information
| Target ID | GM-T08922 |
| Target Name | ACACB |
| Gene ID | 32,100705,116719,706909,100685468,101086680,515338,100066740 |
| Gene Symbol and Synonyms | ACACB,ACACbeta,ACC-beta,ACC2,ACCB,ACCbeta,HACC275 |
| Uniprot Accession | O00763 |
| Uniprot Entry Name | ACACB_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000076555 |
| Target Classification | N/A |
The target: ACACB, gene name: ACACB, also named as ACC2, ACCB, HACC275. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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