Anti-KCJ10/ KCNJ10/ BIRK-10 monoclonal antibody

Anti-KCJ10/ KCNJ10/ BIRK-10 antibody for FACS & in-vivo assay

Target products collectionGo to KCNJ10/KCNJ10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T09423-Ab-1/ GM-Tg-hg-T09423-Ab-2Anti-Human KCNJ10 monoclonal antibodyHuman
GM-Tg-rg-T09423-Ab-1/ GM-Tg-rg-T09423-Ab-2Anti-Rat KCNJ10 monoclonal antibodyRat
GM-Tg-mg-T09423-Ab-1/ GM-Tg-mg-T09423-Ab-2Anti-Mouse KCNJ10 monoclonal antibodyMouse
GM-Tg-cynog-T09423-Ab-1/ GM-Tg-cynog-T09423-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNJ10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T09423-Ab-1/ GM-Tg-felg-T09423-Ab-2Anti-Feline KCNJ10 monoclonal antibodyFeline
GM-Tg-cang-T09423-Ab-1/ GM-Tg-cang-T09423-Ab-2Anti-Canine KCNJ10 monoclonal antibodyCanine
GM-Tg-bovg-T09423-Ab-1/ GM-Tg-bovg-T09423-Ab-2Anti-Bovine KCNJ10 monoclonal antibodyBovine
GM-Tg-equg-T09423-Ab-1/ GM-Tg-equg-T09423-Ab-2Anti-Equine KCNJ10 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T09423-Ab-1/ GM-Tg-hg-T09423-Ab-2; GM-Tg-rg-T09423-Ab-1/ GM-Tg-rg-T09423-Ab-2;
GM-Tg-mg-T09423-Ab-1/ GM-Tg-mg-T09423-Ab-2; GM-Tg-cynog-T09423-Ab-1/ GM-Tg-cynog-T09423-Ab-2;
GM-Tg-felg-T09423-Ab-1/ GM-Tg-felg-T09423-Ab-2; GM-Tg-cang-T09423-Ab-1/ GM-Tg-cang-T09423-Ab-2;
GM-Tg-bovg-T09423-Ab-1/ GM-Tg-bovg-T09423-Ab-2; GM-Tg-equg-T09423-Ab-1/ GM-Tg-equg-T09423-Ab-2
Products NameAnti-KCNJ10 monoclonal antibody
Formatmab
Target NameKCNJ10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNJ10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCJ10/ KCNJ10/ BIRK-10 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP000611human KCNJ10 Lentivirus plasmid
    ORF Viral VectorvGMLP000611human KCNJ10 Lentivirus particle
    ORF Viral VectorpGMLPm001861mouse Kcnj10 Lentivirus plasmid
    ORF Viral VectorvGMLPm001861mouse Kcnj10 Lentivirus particle


    Target information

    Target IDGM-T09423
    Target NameKCNJ10
    Gene ID3766,16513,29718,720180,488635,101097297,533343,100058121
    Gene Symbol and SynonymsBIR10,BIRK-1,BIRK-10,KCNJ10,KCNJ13-PEN,KIR1.2,KIR4.1,SESAME
    Uniprot AccessionP78508,P49655
    Uniprot Entry NameKCJ10_HUMAN,KCJ10_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000177807
    Target ClassificationN/A

    The target: KCNJ10, gene name: KCNJ10, also named as BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME. This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.