Anti-KCJ10/ KCNJ10/ BIRK-10 monoclonal antibody
Anti-KCJ10/ KCNJ10/ BIRK-10 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T09423-Ab-1/ GM-Tg-hg-T09423-Ab-2 | Anti-Human KCNJ10 monoclonal antibody | Human |
GM-Tg-rg-T09423-Ab-1/ GM-Tg-rg-T09423-Ab-2 | Anti-Rat KCNJ10 monoclonal antibody | Rat |
GM-Tg-mg-T09423-Ab-1/ GM-Tg-mg-T09423-Ab-2 | Anti-Mouse KCNJ10 monoclonal antibody | Mouse |
GM-Tg-cynog-T09423-Ab-1/ GM-Tg-cynog-T09423-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNJ10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T09423-Ab-1/ GM-Tg-felg-T09423-Ab-2 | Anti-Feline KCNJ10 monoclonal antibody | Feline |
GM-Tg-cang-T09423-Ab-1/ GM-Tg-cang-T09423-Ab-2 | Anti-Canine KCNJ10 monoclonal antibody | Canine |
GM-Tg-bovg-T09423-Ab-1/ GM-Tg-bovg-T09423-Ab-2 | Anti-Bovine KCNJ10 monoclonal antibody | Bovine |
GM-Tg-equg-T09423-Ab-1/ GM-Tg-equg-T09423-Ab-2 | Anti-Equine KCNJ10 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T09423-Ab-1/ GM-Tg-hg-T09423-Ab-2; GM-Tg-rg-T09423-Ab-1/ GM-Tg-rg-T09423-Ab-2; GM-Tg-mg-T09423-Ab-1/ GM-Tg-mg-T09423-Ab-2; GM-Tg-cynog-T09423-Ab-1/ GM-Tg-cynog-T09423-Ab-2; GM-Tg-felg-T09423-Ab-1/ GM-Tg-felg-T09423-Ab-2; GM-Tg-cang-T09423-Ab-1/ GM-Tg-cang-T09423-Ab-2; GM-Tg-bovg-T09423-Ab-1/ GM-Tg-bovg-T09423-Ab-2; GM-Tg-equg-T09423-Ab-1/ GM-Tg-equg-T09423-Ab-2 |
Products Name | Anti-KCNJ10 monoclonal antibody |
Format | mab |
Target Name | KCNJ10 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-KCNJ10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species KCJ10/ KCNJ10/ BIRK-10 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLP000611 | human KCNJ10 Lentivirus plasmid |
ORF Viral Vector | vGMLP000611 | human KCNJ10 Lentivirus particle |
ORF Viral Vector | pGMLPm001861 | mouse Kcnj10 Lentivirus plasmid |
ORF Viral Vector | vGMLPm001861 | mouse Kcnj10 Lentivirus particle |
Target information
Target ID | GM-T09423 |
Target Name | KCNJ10 |
Gene ID | 3766,16513,29718,720180,488635,101097297,533343,100058121 |
Gene Symbol and Synonyms | BIR10,BIRK-1,BIRK-10,KCNJ10,KCNJ13-PEN,KIR1.2,KIR4.1,SESAME |
Uniprot Accession | P78508,P49655 |
Uniprot Entry Name | KCJ10_HUMAN,KCJ10_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000177807 |
Target Classification | N/A |
The target: KCNJ10, gene name: KCNJ10, also named as BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME. This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.