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Anti-PPBT/ ALPL/ AP-TNAP monoclonal antibody
Anti-PPBT/ ALPL/ AP-TNAP antibody for FACS & in-vivo assay
Go to ALPL/ALPL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T09538-Ab-1/ GM-Tg-hg-T09538-Ab-2 | Anti-Human ALPL monoclonal antibody | Human |
| GM-Tg-rg-T09538-Ab-1/ GM-Tg-rg-T09538-Ab-2 | Anti-Rat ALPL monoclonal antibody | Rat |
| GM-Tg-mg-T09538-Ab-1/ GM-Tg-mg-T09538-Ab-2 | Anti-Mouse ALPL monoclonal antibody | Mouse |
| GM-Tg-cynog-T09538-Ab-1/ GM-Tg-cynog-T09538-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ALPL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T09538-Ab-1/ GM-Tg-felg-T09538-Ab-2 | Anti-Feline ALPL monoclonal antibody | Feline |
| GM-Tg-cang-T09538-Ab-1/ GM-Tg-cang-T09538-Ab-2 | Anti-Canine ALPL monoclonal antibody | Canine |
| GM-Tg-bovg-T09538-Ab-1/ GM-Tg-bovg-T09538-Ab-2 | Anti-Bovine ALPL monoclonal antibody | Bovine |
| GM-Tg-equg-T09538-Ab-1/ GM-Tg-equg-T09538-Ab-2 | Anti-Equine ALPL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T09538-Ab-1/ GM-Tg-hg-T09538-Ab-2; GM-Tg-rg-T09538-Ab-1/ GM-Tg-rg-T09538-Ab-2; GM-Tg-mg-T09538-Ab-1/ GM-Tg-mg-T09538-Ab-2; GM-Tg-cynog-T09538-Ab-1/ GM-Tg-cynog-T09538-Ab-2; GM-Tg-felg-T09538-Ab-1/ GM-Tg-felg-T09538-Ab-2; GM-Tg-cang-T09538-Ab-1/ GM-Tg-cang-T09538-Ab-2; GM-Tg-bovg-T09538-Ab-1/ GM-Tg-bovg-T09538-Ab-2; GM-Tg-equg-T09538-Ab-1/ GM-Tg-equg-T09538-Ab-2 |
| Products Name | Anti-ALPL monoclonal antibody |
| Format | mab |
| Target Name | ALPL |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ALPL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PPBT/ ALPL/ AP-TNAP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000498 | house mouse Alpl Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002741 | mouse Alpl Lentivirus plasmid |
| ORF Viral Vector | vGMAD000498 | house mouse Alpl Adenovirus particle |
| ORF Viral Vector | vGMLPm002741 | mouse Alpl Lentivirus particle |
Target information
| Target ID | GM-T09538 |
| Target Name | ALPL |
| Gene ID | 249,11647,25586,717809,403548,727689,280994,100058275 |
| Gene Symbol and Synonyms | Akp-2,Akp2,ALP,ALPL,AP-TNAP,APTNAP,HOPS,HPPA,HPPC,HPPI,HPPO,PHOA,TNALP,TNAP,TNS-ALP,TNS-AP,TNSALP |
| Uniprot Accession | P05186,P08289,Q29486,P09487 |
| Uniprot Entry Name | PPBT_HUMAN,PPBT_RAT,PPBT_FELCA,PPBT_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000162551 |
| Target Classification | N/A |
The target: ALPL, gene name: ALPL, also named as AP-TNAP, APTNAP, HOPS, TNALP, TNAP, TNSALP. This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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