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Anti-TOP1 monoclonal antibody
Pre-made anti-TOP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TOP1/TOP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T09826-Ab-1/ GM-Tg-hg-T09826-Ab-2 | Anti-Human TOP1 monoclonal antibody | Human |
| GM-Tg-rg-T09826-Ab-1/ GM-Tg-rg-T09826-Ab-2 | Anti-Rat TOP1 monoclonal antibody | Rat |
| GM-Tg-mg-T09826-Ab-1/ GM-Tg-mg-T09826-Ab-2 | Anti-Mouse TOP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T09826-Ab-1/ GM-Tg-cynog-T09826-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TOP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T09826-Ab-1/ GM-Tg-felg-T09826-Ab-2 | Anti-Feline TOP1 monoclonal antibody | Feline |
| GM-Tg-cang-T09826-Ab-1/ GM-Tg-cang-T09826-Ab-2 | Anti-Canine TOP1 monoclonal antibody | Canine |
| GM-Tg-bovg-T09826-Ab-1/ GM-Tg-bovg-T09826-Ab-2 | Anti-Bovine TOP1 monoclonal antibody | Bovine |
| GM-Tg-equg-T09826-Ab-1/ GM-Tg-equg-T09826-Ab-2 | Anti-Equine TOP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T09826-Ab-1/ GM-Tg-hg-T09826-Ab-2; GM-Tg-rg-T09826-Ab-1/ GM-Tg-rg-T09826-Ab-2; GM-Tg-mg-T09826-Ab-1/ GM-Tg-mg-T09826-Ab-2; GM-Tg-cynog-T09826-Ab-1/ GM-Tg-cynog-T09826-Ab-2; GM-Tg-felg-T09826-Ab-1/ GM-Tg-felg-T09826-Ab-2; GM-Tg-cang-T09826-Ab-1/ GM-Tg-cang-T09826-Ab-2; GM-Tg-bovg-T09826-Ab-1/ GM-Tg-bovg-T09826-Ab-2; GM-Tg-equg-T09826-Ab-1/ GM-Tg-equg-T09826-Ab-2 |
| Products Name | Anti-TOP1 monoclonal antibody |
| Format | mab |
| Target Name | TOP1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TOP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T09826-Ag-1 | Recombinant multi-species TOP1/ TOPI protein |
Target information
| Target ID | GM-T09826 |
| Target Name | TOP1 |
| Gene ID | 7150,21969,64550,697300,477229,101093174,534799,100070532 |
| Gene Symbol and Synonyms | Ab2-086,D130064I21Rik,TOP,Top-1,TOP1,TOPI |
| Uniprot Accession | P11387,Q9WUL0 |
| Uniprot Entry Name | TOP1_HUMAN,TOP1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000198900 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: TOP1, gene name: TOP1, also named as TOPI. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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