Anti-LYAM3/ SELP/ CD62 monoclonal antibody

Anti-LYAM3/ SELP/ CD62 antibody for FACS & in-vivo assay

Target products collectionGo to SELP/SELP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T10965-Ab-1/ GM-Tg-hg-T10965-Ab-2Anti-Human SELP monoclonal antibodyHuman
GM-Tg-rg-T10965-Ab-1/ GM-Tg-rg-T10965-Ab-2Anti-Rat SELP monoclonal antibodyRat
GM-Tg-mg-T10965-Ab-1/ GM-Tg-mg-T10965-Ab-2Anti-Mouse SELP monoclonal antibodyMouse
GM-Tg-cynog-T10965-Ab-1/ GM-Tg-cynog-T10965-Ab-2Anti-Cynomolgus/ Rhesus macaque SELP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T10965-Ab-1/ GM-Tg-felg-T10965-Ab-2Anti-Feline SELP monoclonal antibodyFeline
GM-Tg-cang-T10965-Ab-1/ GM-Tg-cang-T10965-Ab-2Anti-Canine SELP monoclonal antibodyCanine
GM-Tg-bovg-T10965-Ab-1/ GM-Tg-bovg-T10965-Ab-2Anti-Bovine SELP monoclonal antibodyBovine
GM-Tg-equg-T10965-Ab-1/ GM-Tg-equg-T10965-Ab-2Anti-Equine SELP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T10965-Ab-1/ GM-Tg-hg-T10965-Ab-2; GM-Tg-rg-T10965-Ab-1/ GM-Tg-rg-T10965-Ab-2;
GM-Tg-mg-T10965-Ab-1/ GM-Tg-mg-T10965-Ab-2; GM-Tg-cynog-T10965-Ab-1/ GM-Tg-cynog-T10965-Ab-2;
GM-Tg-felg-T10965-Ab-1/ GM-Tg-felg-T10965-Ab-2; GM-Tg-cang-T10965-Ab-1/ GM-Tg-cang-T10965-Ab-2;
GM-Tg-bovg-T10965-Ab-1/ GM-Tg-bovg-T10965-Ab-2; GM-Tg-equg-T10965-Ab-1/ GM-Tg-equg-T10965-Ab-2
Products NameAnti-SELP monoclonal antibody
Formatmab
Target NameSELP
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SELP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-123Pre-Made Crizanlizumab biosimilar, Whole mAb, Anti-SELP Antibody: Anti-CD62/CD62P/GMP140/GRMP/LECAM3/PADGEM/PSEL therapeutic antibody
    BiosimilarGMP-Bios-ab-270Pre-Made Inclacumab biosimilar, Whole mAb, Anti-SELP Antibody: Anti-CD62/CD62P/GMP140/GRMP/LECAM3/PADGEM/PSEL therapeutic antibody
    BiosimilarGMP-Bios-INN-1027Pre-Made Torapsel Biosimilar, Fusion Protein targeting SELP fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting CD62/CD62P/GMP140/GRMP/LECAM3/PADGEM/PSEL
    Target AntigenProducts DevelopingMulti-species LYAM3/ SELP/ CD62 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm004369mouse Selp Lentivirus plasmid
    ORF Viral VectorvGMLPm004369mouse Selp Lentivirus particle


    Target information

    Target IDGM-T10965
    Target NameSELP
    Gene ID6403,20344,25651,701277,403994,101083565,281486,100009695
    Gene Symbol and SynonymsCD62,CD62P,GMP-140,GMP140,GRMP,LECAM3,PADGEM,PSEL,PSELECT,SELP
    Uniprot AccessionP16109,P98106,P42201
    Uniprot Entry NameLYAM3_HUMAN,LYAM3_RAT,LYAM3_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseHodgkin's lymphoma, Sepsis
    Gene EnsemblENSG00000174175
    Target ClassificationN/A

    The target: SELP, gene name: SELP, also named as CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL. This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.