Anti-5HT1D/ HTR1D/ 5-HT1D monoclonal antibody

Anti-5HT1D/ HTR1D/ 5-HT1D antibody for FACS & in-vivo assay

Target products collectionGo to HTR1D/HTR1D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T11072-Ab-1/ GM-Tg-hg-T11072-Ab-2Anti-Human HTR1D monoclonal antibodyHuman
GM-Tg-rg-T11072-Ab-1/ GM-Tg-rg-T11072-Ab-2Anti-Rat HTR1D monoclonal antibodyRat
GM-Tg-mg-T11072-Ab-1/ GM-Tg-mg-T11072-Ab-2Anti-Mouse HTR1D monoclonal antibodyMouse
GM-Tg-cynog-T11072-Ab-1/ GM-Tg-cynog-T11072-Ab-2Anti-Cynomolgus/ Rhesus macaque HTR1D monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T11072-Ab-1/ GM-Tg-felg-T11072-Ab-2Anti-Feline HTR1D monoclonal antibodyFeline
GM-Tg-cang-T11072-Ab-1/ GM-Tg-cang-T11072-Ab-2Anti-Canine HTR1D monoclonal antibodyCanine
GM-Tg-bovg-T11072-Ab-1/ GM-Tg-bovg-T11072-Ab-2Anti-Bovine HTR1D monoclonal antibodyBovine
GM-Tg-equg-T11072-Ab-1/ GM-Tg-equg-T11072-Ab-2Anti-Equine HTR1D monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T11072-Ab-1/ GM-Tg-hg-T11072-Ab-2; GM-Tg-rg-T11072-Ab-1/ GM-Tg-rg-T11072-Ab-2;
GM-Tg-mg-T11072-Ab-1/ GM-Tg-mg-T11072-Ab-2; GM-Tg-cynog-T11072-Ab-1/ GM-Tg-cynog-T11072-Ab-2;
GM-Tg-felg-T11072-Ab-1/ GM-Tg-felg-T11072-Ab-2; GM-Tg-cang-T11072-Ab-1/ GM-Tg-cang-T11072-Ab-2;
GM-Tg-bovg-T11072-Ab-1/ GM-Tg-bovg-T11072-Ab-2; GM-Tg-equg-T11072-Ab-1/ GM-Tg-equg-T11072-Ab-2
Products NameAnti-HTR1D monoclonal antibody
Formatmab
Target NameHTR1D
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HTR1D benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species 5HT1D/ HTR1D/ 5-HT1D VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T11072
    Target NameHTR1D
    Gene ID3352,15552,25323,709379,403963,101097077,407136,100071630
    Gene Symbol and Synonyms5-HT-1D,5-HT1D,5HT1D,5htr1d,Gpcr14,HT1DA,HTR1D,HTR1DA,Htr1db,HTRL,RDC4
    Uniprot AccessionP28221,P28565,P11614
    Uniprot Entry Name5HT1D_HUMAN,5HT1D_RAT,5HT1D_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000179546
    Target ClassificationN/A

    The target: HTR1D, gene name: HTR1D, also named as 5-HT1D, HT1DAA, HTRL, RDC4, HTR1D. Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and intestine smooth muscle contraction. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.