Anti-ADA2A/ ADRA2A/ ADRA2 monoclonal antibody
Anti-ADA2A/ ADRA2A/ ADRA2 antibody for FACS & in-vivo assay
Go to ADRA2A/ADRA2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T11448-Ab-1/ GM-Tg-hg-T11448-Ab-2 | Anti-Human ADRA2A monoclonal antibody | Human |
GM-Tg-rg-T11448-Ab-1/ GM-Tg-rg-T11448-Ab-2 | Anti-Rat ADRA2A monoclonal antibody | Rat |
GM-Tg-mg-T11448-Ab-1/ GM-Tg-mg-T11448-Ab-2 | Anti-Mouse ADRA2A monoclonal antibody | Mouse |
GM-Tg-cynog-T11448-Ab-1/ GM-Tg-cynog-T11448-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADRA2A monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T11448-Ab-1/ GM-Tg-felg-T11448-Ab-2 | Anti-Feline ADRA2A monoclonal antibody | Feline |
GM-Tg-cang-T11448-Ab-1/ GM-Tg-cang-T11448-Ab-2 | Anti-Canine ADRA2A monoclonal antibody | Canine |
GM-Tg-bovg-T11448-Ab-1/ GM-Tg-bovg-T11448-Ab-2 | Anti-Bovine ADRA2A monoclonal antibody | Bovine |
GM-Tg-equg-T11448-Ab-1/ GM-Tg-equg-T11448-Ab-2 | Anti-Equine ADRA2A monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T11448-Ab-1/ GM-Tg-hg-T11448-Ab-2; GM-Tg-rg-T11448-Ab-1/ GM-Tg-rg-T11448-Ab-2; GM-Tg-mg-T11448-Ab-1/ GM-Tg-mg-T11448-Ab-2; GM-Tg-cynog-T11448-Ab-1/ GM-Tg-cynog-T11448-Ab-2; GM-Tg-felg-T11448-Ab-1/ GM-Tg-felg-T11448-Ab-2; GM-Tg-cang-T11448-Ab-1/ GM-Tg-cang-T11448-Ab-2; GM-Tg-bovg-T11448-Ab-1/ GM-Tg-bovg-T11448-Ab-2; GM-Tg-equg-T11448-Ab-1/ GM-Tg-equg-T11448-Ab-2 |
Products Name | Anti-ADRA2A monoclonal antibody |
Format | mab |
Target Name | ADRA2A |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-ADRA2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species ADA2A/ ADRA2A/ ADRA2 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLP003730 | human ADRA2A Lentivirus plasmid |
ORF Viral Vector | vGMLP003730 | human ADRA2A Lentivirus particle |
Target information
Target ID | GM-T11448 |
Target Name | ADRA2A |
Gene ID | 150,11551,25083,695684,486888,664736,282135,100147119 |
Gene Symbol and Synonyms | Adra-2,Adra-2a,ADRA2,ADRA2A,ADRA2R,ADRAR,alpha(2A)AR,alpha2-C10,alpha2A,alpha2A-AR,ALPHA2AAR,CA2-47,RATRG20,RG20,ZNF32 |
Uniprot Accession | P08913,P22909,Q28838 |
Uniprot Entry Name | ADA2A_HUMAN,ADA2A_RAT,ADA2A_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000150594 |
Target Classification | GPCR |
The target: ADRA2A, gene name: ADRA2A, also named as ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.