Anti-ADA2A/ ADRA2A/ ADRA2 monoclonal antibody

Anti-ADA2A/ ADRA2A/ ADRA2 antibody for FACS & in-vivo assay

Target products collectionGo to ADRA2A/ADRA2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T11448-Ab-1/ GM-Tg-hg-T11448-Ab-2Anti-Human ADRA2A monoclonal antibodyHuman
GM-Tg-rg-T11448-Ab-1/ GM-Tg-rg-T11448-Ab-2Anti-Rat ADRA2A monoclonal antibodyRat
GM-Tg-mg-T11448-Ab-1/ GM-Tg-mg-T11448-Ab-2Anti-Mouse ADRA2A monoclonal antibodyMouse
GM-Tg-cynog-T11448-Ab-1/ GM-Tg-cynog-T11448-Ab-2Anti-Cynomolgus/ Rhesus macaque ADRA2A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T11448-Ab-1/ GM-Tg-felg-T11448-Ab-2Anti-Feline ADRA2A monoclonal antibodyFeline
GM-Tg-cang-T11448-Ab-1/ GM-Tg-cang-T11448-Ab-2Anti-Canine ADRA2A monoclonal antibodyCanine
GM-Tg-bovg-T11448-Ab-1/ GM-Tg-bovg-T11448-Ab-2Anti-Bovine ADRA2A monoclonal antibodyBovine
GM-Tg-equg-T11448-Ab-1/ GM-Tg-equg-T11448-Ab-2Anti-Equine ADRA2A monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T11448-Ab-1/ GM-Tg-hg-T11448-Ab-2; GM-Tg-rg-T11448-Ab-1/ GM-Tg-rg-T11448-Ab-2;
GM-Tg-mg-T11448-Ab-1/ GM-Tg-mg-T11448-Ab-2; GM-Tg-cynog-T11448-Ab-1/ GM-Tg-cynog-T11448-Ab-2;
GM-Tg-felg-T11448-Ab-1/ GM-Tg-felg-T11448-Ab-2; GM-Tg-cang-T11448-Ab-1/ GM-Tg-cang-T11448-Ab-2;
GM-Tg-bovg-T11448-Ab-1/ GM-Tg-bovg-T11448-Ab-2; GM-Tg-equg-T11448-Ab-1/ GM-Tg-equg-T11448-Ab-2
Products NameAnti-ADRA2A monoclonal antibody
Formatmab
Target NameADRA2A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ADRA2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ADA2A/ ADRA2A/ ADRA2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003730human ADRA2A Lentivirus plasmid
    ORF Viral VectorvGMLP003730human ADRA2A Lentivirus particle


    Target information

    Target IDGM-T11448
    Target NameADRA2A
    Gene ID150,11551,25083,695684,486888,664736,282135,100147119
    Gene Symbol and SynonymsAdra-2,Adra-2a,ADRA2,ADRA2A,ADRA2R,ADRAR,alpha(2A)AR,alpha2-C10,alpha2A,alpha2A-AR,ALPHA2AAR,CA2-47,RATRG20,RG20,ZNF32
    Uniprot AccessionP08913,P22909,Q28838
    Uniprot Entry NameADA2A_HUMAN,ADA2A_RAT,ADA2A_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000150594
    Target ClassificationGPCR

    The target: ADRA2A, gene name: ADRA2A, also named as ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.