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Anti-GNRHR/ GNRHR1/ GRHR monoclonal antibody
Anti-GNRHR/ GNRHR1/ GRHR antibody for FACS & in-vivo assay
Go to GNRHR/GNRHR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T12475-Ab-1/ GM-Tg-hg-T12475-Ab-2 | Anti-Human GNRHR monoclonal antibody | Human |
| GM-Tg-rg-T12475-Ab-1/ GM-Tg-rg-T12475-Ab-2 | Anti-Rat GNRHR monoclonal antibody | Rat |
| GM-Tg-mg-T12475-Ab-1/ GM-Tg-mg-T12475-Ab-2 | Anti-Mouse GNRHR monoclonal antibody | Mouse |
| GM-Tg-cynog-T12475-Ab-1/ GM-Tg-cynog-T12475-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GNRHR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T12475-Ab-1/ GM-Tg-felg-T12475-Ab-2 | Anti-Feline GNRHR monoclonal antibody | Feline |
| GM-Tg-cang-T12475-Ab-1/ GM-Tg-cang-T12475-Ab-2 | Anti-Canine GNRHR monoclonal antibody | Canine |
| GM-Tg-bovg-T12475-Ab-1/ GM-Tg-bovg-T12475-Ab-2 | Anti-Bovine GNRHR monoclonal antibody | Bovine |
| GM-Tg-equg-T12475-Ab-1/ GM-Tg-equg-T12475-Ab-2 | Anti-Equine GNRHR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T12475-Ab-1/ GM-Tg-hg-T12475-Ab-2; GM-Tg-rg-T12475-Ab-1/ GM-Tg-rg-T12475-Ab-2; GM-Tg-mg-T12475-Ab-1/ GM-Tg-mg-T12475-Ab-2; GM-Tg-cynog-T12475-Ab-1/ GM-Tg-cynog-T12475-Ab-2; GM-Tg-felg-T12475-Ab-1/ GM-Tg-felg-T12475-Ab-2; GM-Tg-cang-T12475-Ab-1/ GM-Tg-cang-T12475-Ab-2; GM-Tg-bovg-T12475-Ab-1/ GM-Tg-bovg-T12475-Ab-2; GM-Tg-equg-T12475-Ab-1/ GM-Tg-equg-T12475-Ab-2 |
| Products Name | Anti-GNRHR monoclonal antibody |
| Format | mab |
| Target Name | GNRHR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GNRHR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GNRHR/ GNRHR1/ GRHR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002105 | human GNRHR Lentivirus particle |
| ORF Viral Vector | pGMLP002105 | human GNRHR Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004585 | mouse Gnrhr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004585 | mouse Gnrhr Lentivirus particle |
Target information
| Target ID | GM-T12475 |
| Target Name | GNRHR |
| Gene ID | 2798,14715,81668,711577,403718,101088838,281798,100033874 |
| Gene Symbol and Synonyms | GH1,GnRH-R,GNRHR,GNRHR1,GRHR,HH7,LHRHR,LRHR |
| Uniprot Accession | P30968,P30969,Q8SPZ1,Q9MZI6,P32236,O18821 |
| Uniprot Entry Name | GNRHR_HUMAN,GNRHR_MACMU,GNRHR_RAT,GNRHR_CANLF,GNRHR_BOVIN,GNRHR_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000109163 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: GNRHR, gene name: GNRHR, also named as GNRHR1, GRHR, HH7, LHRHR, LRHR. This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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