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Anti-KPCA/ PRKCA/ AAG6 monoclonal antibody
Anti-KPCA/ PRKCA/ AAG6 antibody for FACS & in-vivo assay
Go to PRKCA/PRKCA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T12808-Ab-1/ GM-Tg-hg-T12808-Ab-2 | Anti-Human PRKCA monoclonal antibody | Human |
| GM-Tg-rg-T12808-Ab-1/ GM-Tg-rg-T12808-Ab-2 | Anti-Rat PRKCA monoclonal antibody | Rat |
| GM-Tg-mg-T12808-Ab-1/ GM-Tg-mg-T12808-Ab-2 | Anti-Mouse PRKCA monoclonal antibody | Mouse |
| GM-Tg-cynog-T12808-Ab-1/ GM-Tg-cynog-T12808-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRKCA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T12808-Ab-1/ GM-Tg-felg-T12808-Ab-2 | Anti-Feline PRKCA monoclonal antibody | Feline |
| GM-Tg-cang-T12808-Ab-1/ GM-Tg-cang-T12808-Ab-2 | Anti-Canine PRKCA monoclonal antibody | Canine |
| GM-Tg-bovg-T12808-Ab-1/ GM-Tg-bovg-T12808-Ab-2 | Anti-Bovine PRKCA monoclonal antibody | Bovine |
| GM-Tg-equg-T12808-Ab-1/ GM-Tg-equg-T12808-Ab-2 | Anti-Equine PRKCA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T12808-Ab-1/ GM-Tg-hg-T12808-Ab-2; GM-Tg-rg-T12808-Ab-1/ GM-Tg-rg-T12808-Ab-2; GM-Tg-mg-T12808-Ab-1/ GM-Tg-mg-T12808-Ab-2; GM-Tg-cynog-T12808-Ab-1/ GM-Tg-cynog-T12808-Ab-2; GM-Tg-felg-T12808-Ab-1/ GM-Tg-felg-T12808-Ab-2; GM-Tg-cang-T12808-Ab-1/ GM-Tg-cang-T12808-Ab-2; GM-Tg-bovg-T12808-Ab-1/ GM-Tg-bovg-T12808-Ab-2; GM-Tg-equg-T12808-Ab-1/ GM-Tg-equg-T12808-Ab-2 |
| Products Name | Anti-PRKCA monoclonal antibody |
| Format | mab |
| Target Name | PRKCA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PRKCA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KPCA/ PRKCA/ AAG6 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000546 | Human PRKCA Adenovirus plasmid |
| ORF Viral Vector | vGMAP000546 | Human PRKCA Adenovirus particle |
| ORF Viral Vector | pGMLPm003122 | mouse Prkca Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003122 | mouse Prkca Lentivirus particle |
Target information
| Target ID | GM-T12808 |
| Target Name | PRKCA |
| Gene ID | 5578,18750,24680,718412,490904,101086433,282001,100063318 |
| Gene Symbol and Synonyms | AAG6,PKC-alpha,PKCA,PKCalpha,PKCI+/-,PKRCA,PRKACA,PRKCA |
| Uniprot Accession | P17252,P05696,P04409 |
| Uniprot Entry Name | KPCA_HUMAN,KPCA_RAT,KPCA_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000154229 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PRKCA, gene name: PRKCA, also named as AAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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