Anti-RXRA monoclonal antibody

Pre-made anti-RXRA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to RXRA/RXRA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T13726-Ab-1/ GM-Tg-hg-T13726-Ab-2Anti-Human RXRA monoclonal antibodyHuman
GM-Tg-rg-T13726-Ab-1/ GM-Tg-rg-T13726-Ab-2Anti-Rat RXRA monoclonal antibodyRat
GM-Tg-mg-T13726-Ab-1/ GM-Tg-mg-T13726-Ab-2Anti-Mouse RXRA monoclonal antibodyMouse
GM-Tg-cynog-T13726-Ab-1/ GM-Tg-cynog-T13726-Ab-2Anti-Cynomolgus/ Rhesus macaque RXRA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T13726-Ab-1/ GM-Tg-felg-T13726-Ab-2Anti-Feline RXRA monoclonal antibodyFeline
GM-Tg-cang-T13726-Ab-1/ GM-Tg-cang-T13726-Ab-2Anti-Canine RXRA monoclonal antibodyCanine
GM-Tg-bovg-T13726-Ab-1/ GM-Tg-bovg-T13726-Ab-2Anti-Bovine RXRA monoclonal antibodyBovine
GM-Tg-equg-T13726-Ab-1/ GM-Tg-equg-T13726-Ab-2Anti-Equine RXRA monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T13726-Ab-1/ GM-Tg-hg-T13726-Ab-2; GM-Tg-rg-T13726-Ab-1/ GM-Tg-rg-T13726-Ab-2;
GM-Tg-mg-T13726-Ab-1/ GM-Tg-mg-T13726-Ab-2; GM-Tg-cynog-T13726-Ab-1/ GM-Tg-cynog-T13726-Ab-2;
GM-Tg-felg-T13726-Ab-1/ GM-Tg-felg-T13726-Ab-2; GM-Tg-cang-T13726-Ab-1/ GM-Tg-cang-T13726-Ab-2;
GM-Tg-bovg-T13726-Ab-1/ GM-Tg-bovg-T13726-Ab-2; GM-Tg-equg-T13726-Ab-1/ GM-Tg-equg-T13726-Ab-2
Products NameAnti-RXRA monoclonal antibody
Formatmab
Target NameRXRA
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-RXRA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T13726-Ag-1Recombinant multi-species RXRA/ NR2B1 protein
    ORF Viral VectorvGMLP001424human RXRA Lentivirus particle
    ORF Viral VectorpGMLP001424human RXRA Lentivirus plasmid
    ORF Viral VectorpGMLPm001785mouse Rxra Lentivirus plasmid
    ORF Viral VectorvGMLPm001785mouse Rxra Lentivirus particle


    Target information

    Target IDGM-T13726
    Target NameRXRA
    Gene ID6256,20181,25271,722068,491278,101085757,507554,100069096
    Gene Symbol and Synonyms9530071D11Rik,NR2B1,RXR-alpha,RXRA,RXRalpha,RXRalpha1
    Uniprot AccessionP19793,Q05343
    Uniprot Entry NameRXRA_HUMAN,RXRA_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000186350
    Target ClassificationNuclear Receptors, Tumor-associated antigen (TAA)

    The target: RXRA, gene name: RXRA, also named as NR2B1. Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.