Anti-FA8/ F8/ AHF monoclonal antibody

Anti-FA8/ F8/ AHF antibody for FACS & in-vivo assay

Target products collectionGo to F8/F8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T14602-Ab-1/ GM-Tg-hg-T14602-Ab-2Anti-Human F8 monoclonal antibodyHuman
GM-Tg-rg-T14602-Ab-1/ GM-Tg-rg-T14602-Ab-2Anti-Rat F8 monoclonal antibodyRat
GM-Tg-mg-T14602-Ab-1/ GM-Tg-mg-T14602-Ab-2Anti-Mouse F8 monoclonal antibodyMouse
GM-Tg-cynog-T14602-Ab-1/ GM-Tg-cynog-T14602-Ab-2Anti-Cynomolgus/ Rhesus macaque F8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T14602-Ab-1/ GM-Tg-felg-T14602-Ab-2Anti-Feline F8 monoclonal antibodyFeline
GM-Tg-cang-T14602-Ab-1/ GM-Tg-cang-T14602-Ab-2Anti-Canine F8 monoclonal antibodyCanine
GM-Tg-bovg-T14602-Ab-1/ GM-Tg-bovg-T14602-Ab-2Anti-Bovine F8 monoclonal antibodyBovine
GM-Tg-equg-T14602-Ab-1/ GM-Tg-equg-T14602-Ab-2Anti-Equine F8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T14602-Ab-1/ GM-Tg-hg-T14602-Ab-2; GM-Tg-rg-T14602-Ab-1/ GM-Tg-rg-T14602-Ab-2;
GM-Tg-mg-T14602-Ab-1/ GM-Tg-mg-T14602-Ab-2; GM-Tg-cynog-T14602-Ab-1/ GM-Tg-cynog-T14602-Ab-2;
GM-Tg-felg-T14602-Ab-1/ GM-Tg-felg-T14602-Ab-2; GM-Tg-cang-T14602-Ab-1/ GM-Tg-cang-T14602-Ab-2;
GM-Tg-bovg-T14602-Ab-1/ GM-Tg-bovg-T14602-Ab-2; GM-Tg-equg-T14602-Ab-1/ GM-Tg-equg-T14602-Ab-2
Products NameAnti-F8 monoclonal antibody
Formatmab
Target NameF8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-F8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-934Pre-Made Omfiloctocog Alfa Biosimilar, Recombinant Protein targeting F8: Recombinant therapeutic protein targeting AHF/F8B/F8C/HEMA/FVIII/DXS1253E
    BiosimilarGMP-Bios-INN-809Pre-Made Efanesoctocog Alfa Biosimilar, Fusion Protein targeting F8 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AHF/F8B/F8C/HEMA/FVIII/DXS1253E
    BiosimilarGMP-Bios-INN-823Pre-Made Efmoroctocog Alfa Biosimilar, Fusion Protein targeting F8 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AHF/F8B/F8C/HEMA/FVIII/DXS1253E
    Target AntigenProducts DevelopingMulti-species FA8/ F8/ AHF VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAP000016Human F8 Adenovirus plasmid
    ORF Viral VectorvGMAD000412human F8 Adenovirus particle
    ORF Viral VectorpGMAD000412human F8 Adenovirus plasmid
    ORF Viral VectorvGMAP000016Human F8 Adenovirus particle
    ORF Viral VectorpGMLP000410human F8 Lentivirus plasmid
    ORF Viral VectorvGMLP000410human F8 Lentivirus particle


    Target information

    Target IDGM-T14602
    Target NameF8
    Gene ID2157,14069,302470,100424151,403875,101092751,100271720,100063026
    Gene Symbol and SynonymsAHF,Cf-8,Cf8,DXS1253E,F8,F8B,F8C,FVIII,HEMA,THPH13
    Uniprot AccessionP00451,O18806
    Uniprot Entry NameFA8_HUMAN,FA8_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000185010
    Target ClassificationN/A

    The target: F8, gene name: F8, also named as AHF, DXS1253EB, F8C, FVIII, HEMA, F8. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa.  This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.