Anti-FA8/ F8/ AHF monoclonal antibody
Anti-FA8/ F8/ AHF antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T14602-Ab-1/ GM-Tg-hg-T14602-Ab-2 | Anti-Human F8 monoclonal antibody | Human |
GM-Tg-rg-T14602-Ab-1/ GM-Tg-rg-T14602-Ab-2 | Anti-Rat F8 monoclonal antibody | Rat |
GM-Tg-mg-T14602-Ab-1/ GM-Tg-mg-T14602-Ab-2 | Anti-Mouse F8 monoclonal antibody | Mouse |
GM-Tg-cynog-T14602-Ab-1/ GM-Tg-cynog-T14602-Ab-2 | Anti-Cynomolgus/ Rhesus macaque F8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T14602-Ab-1/ GM-Tg-felg-T14602-Ab-2 | Anti-Feline F8 monoclonal antibody | Feline |
GM-Tg-cang-T14602-Ab-1/ GM-Tg-cang-T14602-Ab-2 | Anti-Canine F8 monoclonal antibody | Canine |
GM-Tg-bovg-T14602-Ab-1/ GM-Tg-bovg-T14602-Ab-2 | Anti-Bovine F8 monoclonal antibody | Bovine |
GM-Tg-equg-T14602-Ab-1/ GM-Tg-equg-T14602-Ab-2 | Anti-Equine F8 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T14602-Ab-1/ GM-Tg-hg-T14602-Ab-2; GM-Tg-rg-T14602-Ab-1/ GM-Tg-rg-T14602-Ab-2; GM-Tg-mg-T14602-Ab-1/ GM-Tg-mg-T14602-Ab-2; GM-Tg-cynog-T14602-Ab-1/ GM-Tg-cynog-T14602-Ab-2; GM-Tg-felg-T14602-Ab-1/ GM-Tg-felg-T14602-Ab-2; GM-Tg-cang-T14602-Ab-1/ GM-Tg-cang-T14602-Ab-2; GM-Tg-bovg-T14602-Ab-1/ GM-Tg-bovg-T14602-Ab-2; GM-Tg-equg-T14602-Ab-1/ GM-Tg-equg-T14602-Ab-2 |
Products Name | Anti-F8 monoclonal antibody |
Format | mab |
Target Name | F8 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-F8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
Target ID | GM-T14602 |
Target Name | F8 |
Gene ID | 2157,14069,302470,100424151,403875,101092751,100271720,100063026 |
Gene Symbol and Synonyms | AHF,Cf-8,Cf8,DXS1253E,F8,F8B,F8C,FVIII,HEMA,THPH13 |
Uniprot Accession | P00451,O18806 |
Uniprot Entry Name | FA8_HUMAN,FA8_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000185010 |
Target Classification | N/A |
The target: F8, gene name: F8, also named as AHF, DXS1253EB, F8C, FVIII, HEMA, F8. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.