Anti-5HT5A/ HTR5A/ 5-HT5A monoclonal antibody

Anti-5HT5A/ HTR5A/ 5-HT5A antibody for FACS & in-vivo assay

Target products collectionGo to HTR5A/HTR5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T15571-Ab-1/ GM-Tg-hg-T15571-Ab-2Anti-Human HTR5A monoclonal antibodyHuman
GM-Tg-rg-T15571-Ab-1/ GM-Tg-rg-T15571-Ab-2Anti-Rat HTR5A monoclonal antibodyRat
GM-Tg-mg-T15571-Ab-1/ GM-Tg-mg-T15571-Ab-2Anti-Mouse HTR5A monoclonal antibodyMouse
GM-Tg-cynog-T15571-Ab-1/ GM-Tg-cynog-T15571-Ab-2Anti-Cynomolgus/ Rhesus macaque HTR5A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T15571-Ab-1/ GM-Tg-felg-T15571-Ab-2Anti-Feline HTR5A monoclonal antibodyFeline
GM-Tg-cang-T15571-Ab-1/ GM-Tg-cang-T15571-Ab-2Anti-Canine HTR5A monoclonal antibodyCanine
GM-Tg-bovg-T15571-Ab-1/ GM-Tg-bovg-T15571-Ab-2Anti-Bovine HTR5A monoclonal antibodyBovine
GM-Tg-equg-T15571-Ab-1/ GM-Tg-equg-T15571-Ab-2Anti-Equine HTR5A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T15571-Ab-1/ GM-Tg-hg-T15571-Ab-2; GM-Tg-rg-T15571-Ab-1/ GM-Tg-rg-T15571-Ab-2;
GM-Tg-mg-T15571-Ab-1/ GM-Tg-mg-T15571-Ab-2; GM-Tg-cynog-T15571-Ab-1/ GM-Tg-cynog-T15571-Ab-2;
GM-Tg-felg-T15571-Ab-1/ GM-Tg-felg-T15571-Ab-2; GM-Tg-cang-T15571-Ab-1/ GM-Tg-cang-T15571-Ab-2;
GM-Tg-bovg-T15571-Ab-1/ GM-Tg-bovg-T15571-Ab-2; GM-Tg-equg-T15571-Ab-1/ GM-Tg-equg-T15571-Ab-2
Products NameAnti-HTR5A monoclonal antibody
Formatmab
Target NameHTR5A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HTR5A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species 5HT5A/ HTR5A/ 5-HT5A VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T15571
    Target NameHTR5A
    Gene ID3361,15563,25689,716134,482814,101084611,541200,100063709
    Gene Symbol and Synonyms5-HT5A,5HT5A,Htr5,HTR5A,MR22
    Uniprot AccessionP47898,P35364
    Uniprot Entry Name5HT5A_HUMAN,5HT5A_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000157219
    Target ClassificationGPCR

    The target: HTR5A, gene name: HTR5A, also named as 5-HT5A. The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.