Anti-IOD1/ DIO1/ 5DI monoclonal antibody
Anti-IOD1/ DIO1/ 5DI antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T16792-Ab-1/ GM-Tg-hg-T16792-Ab-2 | Anti-Human DIO1 monoclonal antibody | Human |
GM-Tg-rg-T16792-Ab-1/ GM-Tg-rg-T16792-Ab-2 | Anti-Rat DIO1 monoclonal antibody | Rat |
GM-Tg-mg-T16792-Ab-1/ GM-Tg-mg-T16792-Ab-2 | Anti-Mouse DIO1 monoclonal antibody | Mouse |
GM-Tg-cynog-T16792-Ab-1/ GM-Tg-cynog-T16792-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DIO1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T16792-Ab-1/ GM-Tg-felg-T16792-Ab-2 | Anti-Feline DIO1 monoclonal antibody | Feline |
GM-Tg-cang-T16792-Ab-1/ GM-Tg-cang-T16792-Ab-2 | Anti-Canine DIO1 monoclonal antibody | Canine |
GM-Tg-bovg-T16792-Ab-1/ GM-Tg-bovg-T16792-Ab-2 | Anti-Bovine DIO1 monoclonal antibody | Bovine |
GM-Tg-equg-T16792-Ab-1/ GM-Tg-equg-T16792-Ab-2 | Anti-Equine DIO1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T16792-Ab-1/ GM-Tg-hg-T16792-Ab-2; GM-Tg-rg-T16792-Ab-1/ GM-Tg-rg-T16792-Ab-2; GM-Tg-mg-T16792-Ab-1/ GM-Tg-mg-T16792-Ab-2; GM-Tg-cynog-T16792-Ab-1/ GM-Tg-cynog-T16792-Ab-2; GM-Tg-felg-T16792-Ab-1/ GM-Tg-felg-T16792-Ab-2; GM-Tg-cang-T16792-Ab-1/ GM-Tg-cang-T16792-Ab-2; GM-Tg-bovg-T16792-Ab-1/ GM-Tg-bovg-T16792-Ab-2; GM-Tg-equg-T16792-Ab-1/ GM-Tg-equg-T16792-Ab-2 |
Products Name | Anti-DIO1 monoclonal antibody |
Format | mab |
Target Name | DIO1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-DIO1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species IOD1/ DIO1/ 5DI VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP002080 | human DIO1 Lentivirus particle |
ORF Viral Vector | pGMLP002080 | human DIO1 Lentivirus plasmid |
ORF Viral Vector | pGMLPm000360 | mouse Dio1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm000360 | mouse Dio1 Lentivirus particle |
Target information
Target ID | GM-T16792 |
Target Name | DIO1 |
Gene ID | 1733,13370,25430,714739,403635,493798,782446,100050359 |
Gene Symbol and Synonyms | 5DI,D1,DIO1,DIOI,ITDI1,THMA2,TXDI1 |
Uniprot Accession | P49895,P24389,P49894,Q6V915 |
Uniprot Entry Name | IOD1_HUMAN,IOD1_RAT,IOD1_FELCA,IOD1_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000211452 |
Target Classification | N/A |
The target: DIO1, gene name: DIO1, also named as 5DI, TXDI1. The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.