Anti-RET/ RET M918T/ CDHF12 monoclonal antibody

Anti-RET/ RET M918T/ CDHF12 antibody for FACS & in-vivo assay

Target products collectionGo to RET M918T/RET products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T17134-Ab-1/ GM-Tg-hg-T17134-Ab-2Anti-Human RET M918T/RET monoclonal antibodyHuman
GM-Tg-rg-T17134-Ab-1/ GM-Tg-rg-T17134-Ab-2Anti-Rat RET M918T/RET monoclonal antibodyRat
GM-Tg-mg-T17134-Ab-1/ GM-Tg-mg-T17134-Ab-2Anti-Mouse RET M918T/RET monoclonal antibodyMouse
GM-Tg-cynog-T17134-Ab-1/ GM-Tg-cynog-T17134-Ab-2Anti-Cynomolgus/ Rhesus macaque RET M918T/RET monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T17134-Ab-1/ GM-Tg-felg-T17134-Ab-2Anti-Feline RET M918T/RET monoclonal antibodyFeline
GM-Tg-cang-T17134-Ab-1/ GM-Tg-cang-T17134-Ab-2Anti-Canine RET M918T/RET monoclonal antibodyCanine
GM-Tg-bovg-T17134-Ab-1/ GM-Tg-bovg-T17134-Ab-2Anti-Bovine RET M918T/RET monoclonal antibodyBovine
GM-Tg-equg-T17134-Ab-1/ GM-Tg-equg-T17134-Ab-2Anti-Equine RET M918T/RET monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-T17134-Ab-1/ GM-Tg-hg-T17134-Ab-2; GM-Tg-rg-T17134-Ab-1/ GM-Tg-rg-T17134-Ab-2;
GM-Tg-mg-T17134-Ab-1/ GM-Tg-mg-T17134-Ab-2; GM-Tg-cynog-T17134-Ab-1/ GM-Tg-cynog-T17134-Ab-2;
GM-Tg-felg-T17134-Ab-1/ GM-Tg-felg-T17134-Ab-2; GM-Tg-cang-T17134-Ab-1/ GM-Tg-cang-T17134-Ab-2;
GM-Tg-bovg-T17134-Ab-1/ GM-Tg-bovg-T17134-Ab-2; GM-Tg-equg-T17134-Ab-1/ GM-Tg-equg-T17134-Ab-2
Products NameAnti-RET M918T/RET monoclonal antibody
Target NameRET M918T
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-RET M918T benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

    Click to get more Data / Case study about the product.

    Associated products

    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species RET/ RET M918T/ CDHF12 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP001422human RET Lentivirus plasmid
    ORF Viral VectorvGMLP001422human RET Lentivirus particle

    Target information

    Target IDGM-T17134
    Target NameRET M918T
    Gene ID5979,19713,24716,703466,403494,101101086,515924,100146791
    Gene Symbol and Synonymsc-Ret,CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET,RET-ELE1,RET51,RET9
    Uniprot AccessionP07949,G3V9H8
    Uniprot Entry NameRET_HUMAN,RET_RAT
    Protein Sub-locationTransmembrane Protein
    DiseaseNon-Small Cell Lung Cancer, Prostate Cancer
    Gene EnsemblENSG00000165731
    Target ClassificationKinase

    The target: RET M918T, gene name: RET, also named as CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC-ELE1, RET. This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.