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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Cat No.: GM-Tg-hg-T17134-Ab

Pre-made anti-RET M918T benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-RET M918T mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

The target: RET M918T, gene name: RET, also named as CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC-ELE1, RET. This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017].

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Catalog No.List Price (In USD)Discount Price (In USD)Qty (Quantity)Sum (In USD)
GM-Tg-hg-T17134-Ab-1-1mg51503090
GM-Tg-hg-T17134-Ab-1-10mgInquiryInquiry
GM-Tg-hg-T17134-Ab-1-100mgInquiryInquiry
GM-Tg-hg-T17134-Ab-2-1mg51503090
GM-Tg-hg-T17134-Ab-2-10mgInquiryInquiry
GM-Tg-hg-T17134-Ab-2-100mgInquiryInquiry
GM-Tg-hg-T17134-Ab-xmgInquiryInquiry
Shipping Cost:760.00
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Description

Catalog No.GM-Tg-hg-T17134-Ab-1, GM-Tg-hg-T17134-Ab-2
Products Name Anti-RET M918T/RET monoclonal antibody
Formatmab
Target NameRET M918T
Gene IDRET
Gene NameRET
Gene AliasCDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC-ELE1, RET
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
Species ReactivityHuman(H)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RET M918T benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.