Anti-KCNA5/ ATFB7/ HCK1 monoclonal antibody

Anti-KCNA5/ ATFB7/ HCK1 antibody for FACS & in-vivo assay

Target products collectionGo to KCNA5/KCNA5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T17569-Ab-1/ GM-Tg-hg-T17569-Ab-2Anti-Human KCNA5 monoclonal antibodyHuman
GM-Tg-rg-T17569-Ab-1/ GM-Tg-rg-T17569-Ab-2Anti-Rat KCNA5 monoclonal antibodyRat
GM-Tg-mg-T17569-Ab-1/ GM-Tg-mg-T17569-Ab-2Anti-Mouse KCNA5 monoclonal antibodyMouse
GM-Tg-cynog-T17569-Ab-1/ GM-Tg-cynog-T17569-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNA5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T17569-Ab-1/ GM-Tg-felg-T17569-Ab-2Anti-Feline KCNA5 monoclonal antibodyFeline
GM-Tg-cang-T17569-Ab-1/ GM-Tg-cang-T17569-Ab-2Anti-Canine KCNA5 monoclonal antibodyCanine
GM-Tg-bovg-T17569-Ab-1/ GM-Tg-bovg-T17569-Ab-2Anti-Bovine KCNA5 monoclonal antibodyBovine
GM-Tg-equg-T17569-Ab-1/ GM-Tg-equg-T17569-Ab-2Anti-Equine KCNA5 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T17569-Ab-1/ GM-Tg-hg-T17569-Ab-2; GM-Tg-rg-T17569-Ab-1/ GM-Tg-rg-T17569-Ab-2;
GM-Tg-mg-T17569-Ab-1/ GM-Tg-mg-T17569-Ab-2; GM-Tg-cynog-T17569-Ab-1/ GM-Tg-cynog-T17569-Ab-2;
GM-Tg-felg-T17569-Ab-1/ GM-Tg-felg-T17569-Ab-2; GM-Tg-cang-T17569-Ab-1/ GM-Tg-cang-T17569-Ab-2;
GM-Tg-bovg-T17569-Ab-1/ GM-Tg-bovg-T17569-Ab-2; GM-Tg-equg-T17569-Ab-1/ GM-Tg-equg-T17569-Ab-2
Products NameAnti-KCNA5 monoclonal antibody
Formatmab
Target NameKCNA5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNA5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCNA5/ ATFB7/ HCK1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T17569
    Target NameKCNA5
    Gene ID3741,16493,25470,711886,403995,101100573,508960,100051720
    Gene Symbol and SynonymsATFB7,HCK1,HK2,HPCN1,KCNA5,Kv1,KV1.5,PCN1
    Uniprot AccessionP22460,P19024
    Uniprot Entry NameKCNA5_HUMAN,KCNA5_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000130037
    Target ClassificationIon Channel

    The target: KCNA5, gene name: KCNA5, also named as ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1. Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.