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Anti-UROK/ PLAU/ ATF monoclonal antibody
Anti-UROK/ PLAU/ ATF antibody for FACS & in-vivo assay
Go to PLAU/PLAU products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T17758-Ab-1/ GM-Tg-hg-T17758-Ab-2 | Anti-Human PLAU monoclonal antibody | Human |
| GM-Tg-rg-T17758-Ab-1/ GM-Tg-rg-T17758-Ab-2 | Anti-Rat PLAU monoclonal antibody | Rat |
| GM-Tg-mg-T17758-Ab-1/ GM-Tg-mg-T17758-Ab-2 | Anti-Mouse PLAU monoclonal antibody | Mouse |
| GM-Tg-cynog-T17758-Ab-1/ GM-Tg-cynog-T17758-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLAU monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T17758-Ab-1/ GM-Tg-felg-T17758-Ab-2 | Anti-Feline PLAU monoclonal antibody | Feline |
| GM-Tg-cang-T17758-Ab-1/ GM-Tg-cang-T17758-Ab-2 | Anti-Canine PLAU monoclonal antibody | Canine |
| GM-Tg-bovg-T17758-Ab-1/ GM-Tg-bovg-T17758-Ab-2 | Anti-Bovine PLAU monoclonal antibody | Bovine |
| GM-Tg-equg-T17758-Ab-1/ GM-Tg-equg-T17758-Ab-2 | Anti-Equine PLAU monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T17758-Ab-1/ GM-Tg-hg-T17758-Ab-2; GM-Tg-rg-T17758-Ab-1/ GM-Tg-rg-T17758-Ab-2; GM-Tg-mg-T17758-Ab-1/ GM-Tg-mg-T17758-Ab-2; GM-Tg-cynog-T17758-Ab-1/ GM-Tg-cynog-T17758-Ab-2; GM-Tg-felg-T17758-Ab-1/ GM-Tg-felg-T17758-Ab-2; GM-Tg-cang-T17758-Ab-1/ GM-Tg-cang-T17758-Ab-2; GM-Tg-bovg-T17758-Ab-1/ GM-Tg-bovg-T17758-Ab-2; GM-Tg-equg-T17758-Ab-1/ GM-Tg-equg-T17758-Ab-2 |
| Products Name | Anti-PLAU monoclonal antibody |
| Format | mab |
| Target Name | PLAU |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLAU benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species UROK/ PLAU/ ATF VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAD000145 | human PLAU Adenovirus particle |
| ORF Viral Vector | pGMAD000145 | human PLAU Adenovirus plasmid |
| ORF Viral Vector | pGMLPm005320 | mouse Plau Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005320 | mouse Plau Lentivirus particle |
Target information
| Target ID | GM-T17758 |
| Target Name | PLAU |
| Gene ID | 5328,18792,25619,705853,403426,101098338,281408,100072886 |
| Gene Symbol and Synonyms | ATF,BDPLT5,PLAU,QPD,u-PA,UPA,UPAM,URK |
| Uniprot Accession | P00749,P29598,Q05589 |
| Uniprot Entry Name | UROK_HUMAN,UROK_RAT,UROK_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Dent disease |
| Gene Ensembl | ENSG00000122861 |
| Target Classification | N/A |
The target: PLAU, gene name: PLAU, also named as ATF, BDPLT5, QPD, UPA, URK, u-PA. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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