Anti-GUC2D/ GUCY2D/ CACD1 monoclonal antibody

Anti-GUC2D/ GUCY2D/ CACD1 antibody for FACS & in-vivo assay

Target products collectionGo to GUCY2D/GUCY2D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T19693-Ab-1/ GM-Tg-hg-T19693-Ab-2Anti-Human GUCY2D monoclonal antibodyHuman
GM-Tg-rg-T19693-Ab-1/ GM-Tg-rg-T19693-Ab-2Anti-Rat GUCY2D monoclonal antibodyRat
GM-Tg-mg-T19693-Ab-1/ GM-Tg-mg-T19693-Ab-2Anti-Mouse GUCY2D monoclonal antibodyMouse
GM-Tg-cynog-T19693-Ab-1/ GM-Tg-cynog-T19693-Ab-2Anti-Cynomolgus/ Rhesus macaque GUCY2D monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T19693-Ab-1/ GM-Tg-felg-T19693-Ab-2Anti-Feline GUCY2D monoclonal antibodyFeline
GM-Tg-cang-T19693-Ab-1/ GM-Tg-cang-T19693-Ab-2Anti-Canine GUCY2D monoclonal antibodyCanine
GM-Tg-bovg-T19693-Ab-1/ GM-Tg-bovg-T19693-Ab-2Anti-Bovine GUCY2D monoclonal antibodyBovine
GM-Tg-equg-T19693-Ab-1/ GM-Tg-equg-T19693-Ab-2Anti-Equine GUCY2D monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T19693-Ab-1/ GM-Tg-hg-T19693-Ab-2; GM-Tg-rg-T19693-Ab-1/ GM-Tg-rg-T19693-Ab-2;
GM-Tg-mg-T19693-Ab-1/ GM-Tg-mg-T19693-Ab-2; GM-Tg-cynog-T19693-Ab-1/ GM-Tg-cynog-T19693-Ab-2;
GM-Tg-felg-T19693-Ab-1/ GM-Tg-felg-T19693-Ab-2; GM-Tg-cang-T19693-Ab-1/ GM-Tg-cang-T19693-Ab-2;
GM-Tg-bovg-T19693-Ab-1/ GM-Tg-bovg-T19693-Ab-2; GM-Tg-equg-T19693-Ab-1/ GM-Tg-equg-T19693-Ab-2
Products NameAnti-GUCY2D monoclonal antibody
Formatmab
Target NameGUCY2D
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GUCY2D benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GUC2D/ GUCY2D/ CACD1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T19693
    Target NameGUCY2D
    Gene ID3000,14919,79222,716734,403863,101101009,282245,100073037
    Gene Symbol and SynonymsCACD,CACD1,CG-E,CORD5,CORD6,CSNB1I,CYGD,GC-E,GC1,GUC1A4,GUC2D,GUCY2D,Gucy2e,LCA,LCA1,RCD2,retGC,RETGC-1,ROS-GC1,ROSGC
    Uniprot AccessionQ02846,P51840,O19179,P55203
    Uniprot Entry NameGUC2D_HUMAN,GUC2E_RAT,GUC2D_CANLF,GUC2D_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000132518
    Target ClassificationN/A

    The target: GUCY2D, gene name: GUCY2D, also named as CACD1, CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RCD2, RETGC-1, ROS-GC1, ROSGC, retGC. This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.