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Anti-ALAD monoclonal antibody
Pre-made anti-ALAD monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ALAD/ALAD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T20514-Ab-1/ GM-Tg-hg-T20514-Ab-2 | Anti-Human ALAD monoclonal antibody | Human |
| GM-Tg-rg-T20514-Ab-1/ GM-Tg-rg-T20514-Ab-2 | Anti-Rat ALAD monoclonal antibody | Rat |
| GM-Tg-mg-T20514-Ab-1/ GM-Tg-mg-T20514-Ab-2 | Anti-Mouse ALAD monoclonal antibody | Mouse |
| GM-Tg-cynog-T20514-Ab-1/ GM-Tg-cynog-T20514-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ALAD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T20514-Ab-1/ GM-Tg-felg-T20514-Ab-2 | Anti-Feline ALAD monoclonal antibody | Feline |
| GM-Tg-cang-T20514-Ab-1/ GM-Tg-cang-T20514-Ab-2 | Anti-Canine ALAD monoclonal antibody | Canine |
| GM-Tg-bovg-T20514-Ab-1/ GM-Tg-bovg-T20514-Ab-2 | Anti-Bovine ALAD monoclonal antibody | Bovine |
| GM-Tg-equg-T20514-Ab-1/ GM-Tg-equg-T20514-Ab-2 | Anti-Equine ALAD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T20514-Ab-1/ GM-Tg-hg-T20514-Ab-2; GM-Tg-rg-T20514-Ab-1/ GM-Tg-rg-T20514-Ab-2; GM-Tg-mg-T20514-Ab-1/ GM-Tg-mg-T20514-Ab-2; GM-Tg-cynog-T20514-Ab-1/ GM-Tg-cynog-T20514-Ab-2; GM-Tg-felg-T20514-Ab-1/ GM-Tg-felg-T20514-Ab-2; GM-Tg-cang-T20514-Ab-1/ GM-Tg-cang-T20514-Ab-2; GM-Tg-bovg-T20514-Ab-1/ GM-Tg-bovg-T20514-Ab-2; GM-Tg-equg-T20514-Ab-1/ GM-Tg-equg-T20514-Ab-2 |
| Products Name | Anti-ALAD monoclonal antibody |
| Format | mab |
| Target Name | ALAD |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ALAD monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T20514-Ag-1 | Recombinant multi-species HEM2/ ALAD/ ALADH protein |
| ORF Viral Vector | vGMLP000780 | human ALAD Lentivirus particle |
| ORF Viral Vector | pGMLP000780 | human ALAD Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000512 | mouse Alad Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000512 | mouse Alad Lentivirus particle |
Target information
| Target ID | GM-T20514 |
| Target Name | ALAD |
| Gene ID | 210,17025,25374,705193,474808,101096680,510679,100052763 |
| Gene Symbol and Synonyms | ALAD,ALADH,ALADR,aminolevulinatedelta-dehydratase,Lv,PBGS |
| Uniprot Accession | P13716,P06214,Q58DK5 |
| Uniprot Entry Name | HEM2_HUMAN,HEM2_RAT,HEM2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000148218 |
| Target Classification | N/A |
The target: ALAD, gene name: ALAD, also named as ALADH, PBGS. The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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