Anti-ACM4/ CHRM4/ HM4 monoclonal antibody
Anti-ACM4/ CHRM4/ HM4 antibody for FACS & in-vivo assay
Go to CHRM4/CHRM4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T20709-Ab-1/ GM-Tg-hg-T20709-Ab-2 | Anti-Human CHRM4 monoclonal antibody | Human |
GM-Tg-rg-T20709-Ab-1/ GM-Tg-rg-T20709-Ab-2 | Anti-Rat CHRM4 monoclonal antibody | Rat |
GM-Tg-mg-T20709-Ab-1/ GM-Tg-mg-T20709-Ab-2 | Anti-Mouse CHRM4 monoclonal antibody | Mouse |
GM-Tg-cynog-T20709-Ab-1/ GM-Tg-cynog-T20709-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRM4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T20709-Ab-1/ GM-Tg-felg-T20709-Ab-2 | Anti-Feline CHRM4 monoclonal antibody | Feline |
GM-Tg-cang-T20709-Ab-1/ GM-Tg-cang-T20709-Ab-2 | Anti-Canine CHRM4 monoclonal antibody | Canine |
GM-Tg-bovg-T20709-Ab-1/ GM-Tg-bovg-T20709-Ab-2 | Anti-Bovine CHRM4 monoclonal antibody | Bovine |
GM-Tg-equg-T20709-Ab-1/ GM-Tg-equg-T20709-Ab-2 | Anti-Equine CHRM4 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T20709-Ab-1/ GM-Tg-hg-T20709-Ab-2; GM-Tg-rg-T20709-Ab-1/ GM-Tg-rg-T20709-Ab-2; GM-Tg-mg-T20709-Ab-1/ GM-Tg-mg-T20709-Ab-2; GM-Tg-cynog-T20709-Ab-1/ GM-Tg-cynog-T20709-Ab-2; GM-Tg-felg-T20709-Ab-1/ GM-Tg-felg-T20709-Ab-2; GM-Tg-cang-T20709-Ab-1/ GM-Tg-cang-T20709-Ab-2; GM-Tg-bovg-T20709-Ab-1/ GM-Tg-bovg-T20709-Ab-2; GM-Tg-equg-T20709-Ab-1/ GM-Tg-equg-T20709-Ab-2 |
Products Name | Anti-CHRM4 monoclonal antibody |
Format | mab |
Target Name | CHRM4 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CHRM4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species ACM4/ CHRM4/ HM4 VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T20709 |
Target Name | CHRM4 |
Gene ID | 1132,12672,25111,574195,611314,101088360,512928,102147631 |
Gene Symbol and Synonyms | AChR M4,Chrm-4,CHRM4,HM4,M3R,M4,M4R,mm4 mAChR |
Uniprot Accession | P08173,P08485,P41986 |
Uniprot Entry Name | ACM4_HUMAN,ACM4_RAT,ACM4_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000180720 |
Target Classification | GPCR |
The target: CHRM4, gene name: CHRM4, also named as HM4, M4R. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.