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Anti-NMDE1/ NMDAR2A/ GRIN2A monoclonal antibody
Anti-NMDE1/ NMDAR2A/ GRIN2A antibody for FACS & in-vivo assay
Go to NMDAR2A/GRIN2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T22285-Ab-1/ GM-Tg-hg-T22285-Ab-2 | Anti-Human NMDAR2A/GRIN2A monoclonal antibody | Human |
| GM-Tg-rg-T22285-Ab-1/ GM-Tg-rg-T22285-Ab-2 | Anti-Rat NMDAR2A/GRIN2A monoclonal antibody | Rat |
| GM-Tg-mg-T22285-Ab-1/ GM-Tg-mg-T22285-Ab-2 | Anti-Mouse NMDAR2A/GRIN2A monoclonal antibody | Mouse |
| GM-Tg-cynog-T22285-Ab-1/ GM-Tg-cynog-T22285-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NMDAR2A/GRIN2A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T22285-Ab-1/ GM-Tg-felg-T22285-Ab-2 | Anti-Feline NMDAR2A/GRIN2A monoclonal antibody | Feline |
| GM-Tg-cang-T22285-Ab-1/ GM-Tg-cang-T22285-Ab-2 | Anti-Canine NMDAR2A/GRIN2A monoclonal antibody | Canine |
| GM-Tg-bovg-T22285-Ab-1/ GM-Tg-bovg-T22285-Ab-2 | Anti-Bovine NMDAR2A/GRIN2A monoclonal antibody | Bovine |
| GM-Tg-equg-T22285-Ab-1/ GM-Tg-equg-T22285-Ab-2 | Anti-Equine NMDAR2A/GRIN2A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T22285-Ab-1/ GM-Tg-hg-T22285-Ab-2; GM-Tg-rg-T22285-Ab-1/ GM-Tg-rg-T22285-Ab-2; GM-Tg-mg-T22285-Ab-1/ GM-Tg-mg-T22285-Ab-2; GM-Tg-cynog-T22285-Ab-1/ GM-Tg-cynog-T22285-Ab-2; GM-Tg-felg-T22285-Ab-1/ GM-Tg-felg-T22285-Ab-2; GM-Tg-cang-T22285-Ab-1/ GM-Tg-cang-T22285-Ab-2; GM-Tg-bovg-T22285-Ab-1/ GM-Tg-bovg-T22285-Ab-2; GM-Tg-equg-T22285-Ab-1/ GM-Tg-equg-T22285-Ab-2 |
| Products Name | Anti-NMDAR2A/GRIN2A monoclonal antibody |
| Format | mab |
| Target Name | NMDAR2A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NMDAR2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NMDE1/ NMDAR2A/ GRIN2A VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T22285 |
| Target Name | NMDAR2A |
| Gene ID | 2903,14811,24409,100429880,490012,101086110,112444298,100051329 |
| Gene Symbol and Synonyms | EPND,FESD,GluN2A,GluRepsilon1,GRIN2A,LKS,NMDAR2A,NR2A |
| Uniprot Accession | Q12879,Q00959 |
| Uniprot Entry Name | NMDE1_HUMAN,NMDE1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000183454 |
| Target Classification | N/A |
The target: NMDAR2A, gene name: GRIN2A, also named as EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A. This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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