Anti-PGR monoclonal antibody

Pre-made anti-PGR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PGR/PGR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T22939-Ab-1/ GM-Tg-hg-T22939-Ab-2Anti-Human PGR monoclonal antibodyHuman
GM-Tg-rg-T22939-Ab-1/ GM-Tg-rg-T22939-Ab-2Anti-Rat PGR monoclonal antibodyRat
GM-Tg-mg-T22939-Ab-1/ GM-Tg-mg-T22939-Ab-2Anti-Mouse PGR monoclonal antibodyMouse
GM-Tg-cynog-T22939-Ab-1/ GM-Tg-cynog-T22939-Ab-2Anti-Cynomolgus/ Rhesus macaque PGR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T22939-Ab-1/ GM-Tg-felg-T22939-Ab-2Anti-Feline PGR monoclonal antibodyFeline
GM-Tg-cang-T22939-Ab-1/ GM-Tg-cang-T22939-Ab-2Anti-Canine PGR monoclonal antibodyCanine
GM-Tg-bovg-T22939-Ab-1/ GM-Tg-bovg-T22939-Ab-2Anti-Bovine PGR monoclonal antibodyBovine
GM-Tg-equg-T22939-Ab-1/ GM-Tg-equg-T22939-Ab-2Anti-Equine PGR monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T22939-Ab-1/ GM-Tg-hg-T22939-Ab-2; GM-Tg-rg-T22939-Ab-1/ GM-Tg-rg-T22939-Ab-2;
GM-Tg-mg-T22939-Ab-1/ GM-Tg-mg-T22939-Ab-2; GM-Tg-cynog-T22939-Ab-1/ GM-Tg-cynog-T22939-Ab-2;
GM-Tg-felg-T22939-Ab-1/ GM-Tg-felg-T22939-Ab-2; GM-Tg-cang-T22939-Ab-1/ GM-Tg-cang-T22939-Ab-2;
GM-Tg-bovg-T22939-Ab-1/ GM-Tg-bovg-T22939-Ab-2; GM-Tg-equg-T22939-Ab-1/ GM-Tg-equg-T22939-Ab-2
Products NameAnti-PGR monoclonal antibody
Formatmab
Target NamePGR
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PGR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T22939-Ag-1Recombinant multi-species PRGR/ PGR/ NR3C3 protein


    Target information

    Target IDGM-T22939
    Target NamePGR
    Gene ID5241,18667,25154,613024,403621,101098742,100848466,100033883
    Gene Symbol and Synonyms9930019P03Rik,NR3C3,PGR,PR,PR-A,PR-B
    Uniprot AccessionP06401,Q63449,Q9GLW0
    Uniprot Entry NamePRGR_HUMAN,PRGR_RAT,PRGR_CANLF
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    Diseaseprostate cancer
    Gene EnsemblENSG00000082175
    Target ClassificationNuclear Receptors

    The target: PGR, gene name: PGR, also named as NR3C3, PR. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.