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Anti-CYP11A1 monoclonal antibody
Pre-made anti-CYP11A1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CYP11A1/CYP11A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23145-Ab-1/ GM-Tg-hg-T23145-Ab-2 | Anti-Human CYP11A1 monoclonal antibody | Human |
| GM-Tg-rg-T23145-Ab-1/ GM-Tg-rg-T23145-Ab-2 | Anti-Rat CYP11A1 monoclonal antibody | Rat |
| GM-Tg-mg-T23145-Ab-1/ GM-Tg-mg-T23145-Ab-2 | Anti-Mouse CYP11A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T23145-Ab-1/ GM-Tg-cynog-T23145-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYP11A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23145-Ab-1/ GM-Tg-felg-T23145-Ab-2 | Anti-Feline CYP11A1 monoclonal antibody | Feline |
| GM-Tg-cang-T23145-Ab-1/ GM-Tg-cang-T23145-Ab-2 | Anti-Canine CYP11A1 monoclonal antibody | Canine |
| GM-Tg-bovg-T23145-Ab-1/ GM-Tg-bovg-T23145-Ab-2 | Anti-Bovine CYP11A1 monoclonal antibody | Bovine |
| GM-Tg-equg-T23145-Ab-1/ GM-Tg-equg-T23145-Ab-2 | Anti-Equine CYP11A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23145-Ab-1/ GM-Tg-hg-T23145-Ab-2; GM-Tg-rg-T23145-Ab-1/ GM-Tg-rg-T23145-Ab-2; GM-Tg-mg-T23145-Ab-1/ GM-Tg-mg-T23145-Ab-2; GM-Tg-cynog-T23145-Ab-1/ GM-Tg-cynog-T23145-Ab-2; GM-Tg-felg-T23145-Ab-1/ GM-Tg-felg-T23145-Ab-2; GM-Tg-cang-T23145-Ab-1/ GM-Tg-cang-T23145-Ab-2; GM-Tg-bovg-T23145-Ab-1/ GM-Tg-bovg-T23145-Ab-2; GM-Tg-equg-T23145-Ab-1/ GM-Tg-equg-T23145-Ab-2 |
| Products Name | Anti-CYP11A1 monoclonal antibody |
| Format | mab |
| Target Name | CYP11A1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CYP11A1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T23145-Ag-1 | Recombinant multi-species CP11A/ CYP11A1/ CYP11A protein |
| ORF Viral Vector | vGMLP002905 | human CYP11A1 Lentivirus particle |
| ORF Viral Vector | pGMLP002905 | human CYP11A1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005350 | mouse Cyp11a1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005350 | mouse Cyp11a1 Lentivirus particle |
Target information
| Target ID | GM-T23145 |
| Target Name | CYP11A1 |
| Gene ID | 1583,13070,29680,708065,478365,101085980,338048,100034229 |
| Gene Symbol and Synonyms | cscc,CYP11A,CYP11A1,CYPXIA1,D9Ertd411e,P450(scc),P450SCC,Scc |
| Uniprot Accession | P05108,P14137,P00189,O46515 |
| Uniprot Entry Name | CP11A_HUMAN,CP11A_RAT,CP11A_BOVIN,CP11A_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000140459 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CYP11A1, gene name: CYP11A1, also named as CYP11A, CYPXIA1, P450SCC. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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