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Anti-VWF/ F8VWF/ VWD functional antibody
Anti-VWF/ F8VWF/ VWD functional antibody for cell culture, ELISA & in-vivo assay
Go to VWF/VWF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23348-Ab-1/ GM-Tg-hg-T23348-Ab-2 | Anti-Human VWF monoclonal antibody | Human |
| GM-Tg-rg-T23348-Ab-1/ GM-Tg-rg-T23348-Ab-2 | Anti-Rat VWF monoclonal antibody | Rat |
| GM-Tg-mg-T23348-Ab-1/ GM-Tg-mg-T23348-Ab-2 | Anti-Mouse VWF monoclonal antibody | Mouse |
| GM-Tg-cynog-T23348-Ab-1/ GM-Tg-cynog-T23348-Ab-2 | Anti-Cynomolgus/ Rhesus macaque VWF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23348-Ab-1/ GM-Tg-felg-T23348-Ab-2 | Anti-Feline VWF monoclonal antibody | Feline |
| GM-Tg-cang-T23348-Ab-1/ GM-Tg-cang-T23348-Ab-2 | Anti-Canine VWF monoclonal antibody | Canine |
| GM-Tg-bovg-T23348-Ab-1/ GM-Tg-bovg-T23348-Ab-2 | Anti-Bovine VWF monoclonal antibody | Bovine |
| GM-Tg-equg-T23348-Ab-1/ GM-Tg-equg-T23348-Ab-2 | Anti-Equine VWF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23348-Ab-1/ GM-Tg-hg-T23348-Ab-2; GM-Tg-rg-T23348-Ab-1/ GM-Tg-rg-T23348-Ab-2; GM-Tg-mg-T23348-Ab-1/ GM-Tg-mg-T23348-Ab-2; GM-Tg-cynog-T23348-Ab-1/ GM-Tg-cynog-T23348-Ab-2; GM-Tg-felg-T23348-Ab-1/ GM-Tg-felg-T23348-Ab-2; GM-Tg-cang-T23348-Ab-1/ GM-Tg-cang-T23348-Ab-2; GM-Tg-bovg-T23348-Ab-1/ GM-Tg-bovg-T23348-Ab-2; GM-Tg-equg-T23348-Ab-1/ GM-Tg-equg-T23348-Ab-2 |
| Products Name | Anti-VWF monoclonal antibody |
| Format | mab |
| Target Name | VWF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-VWF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-093 | Pre-Made Caplacizumab biosimilar, Nanobody, Anti-VWF Antibody: Anti-F8VWF/VWD therapeutic antibody |
| Target Antigen | GM-Tg-g-T23348-Ag-1 | Recombinant multi-species VWF/ F8VWF/ VWD protein |
Target information
| Target ID | GM-T23348 |
| Target Name | VWF |
| Gene ID | 7450,22371,116669,722019,399544,493760,280958,100059472 |
| Gene Symbol and Synonyms | 6820430P06Rik,B130011O06Rik,C630030D09,F8VWF,VWD,VWF |
| Uniprot Accession | P04275,Q62935,Q28295,P80012 |
| Uniprot Entry Name | VWF_HUMAN,VWF_RAT,VWF_CANLF,VWF_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000110799 |
| Target Classification | N/A |
The target: VWF, gene name: VWF, also named as F8VWF, VWD. This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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