- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-EDNRA/ ET-A/ ETA monoclonal antibody
Anti-EDNRA/ ET-A/ ETA antibody for FACS & in-vivo assay
Go to EDNRA/EDNRA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23499-Ab-1/ GM-Tg-hg-T23499-Ab-2 | Anti-Human EDNRA monoclonal antibody | Human |
| GM-Tg-rg-T23499-Ab-1/ GM-Tg-rg-T23499-Ab-2 | Anti-Rat EDNRA monoclonal antibody | Rat |
| GM-Tg-mg-T23499-Ab-1/ GM-Tg-mg-T23499-Ab-2 | Anti-Mouse EDNRA monoclonal antibody | Mouse |
| GM-Tg-cynog-T23499-Ab-1/ GM-Tg-cynog-T23499-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EDNRA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23499-Ab-1/ GM-Tg-felg-T23499-Ab-2 | Anti-Feline EDNRA monoclonal antibody | Feline |
| GM-Tg-cang-T23499-Ab-1/ GM-Tg-cang-T23499-Ab-2 | Anti-Canine EDNRA monoclonal antibody | Canine |
| GM-Tg-bovg-T23499-Ab-1/ GM-Tg-bovg-T23499-Ab-2 | Anti-Bovine EDNRA monoclonal antibody | Bovine |
| GM-Tg-equg-T23499-Ab-1/ GM-Tg-equg-T23499-Ab-2 | Anti-Equine EDNRA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23499-Ab-1/ GM-Tg-hg-T23499-Ab-2; GM-Tg-rg-T23499-Ab-1/ GM-Tg-rg-T23499-Ab-2; GM-Tg-mg-T23499-Ab-1/ GM-Tg-mg-T23499-Ab-2; GM-Tg-cynog-T23499-Ab-1/ GM-Tg-cynog-T23499-Ab-2; GM-Tg-felg-T23499-Ab-1/ GM-Tg-felg-T23499-Ab-2; GM-Tg-cang-T23499-Ab-1/ GM-Tg-cang-T23499-Ab-2; GM-Tg-bovg-T23499-Ab-1/ GM-Tg-bovg-T23499-Ab-2; GM-Tg-equg-T23499-Ab-1/ GM-Tg-equg-T23499-Ab-2 |
| Products Name | Anti-EDNRA monoclonal antibody |
| Format | mab |
| Target Name | EDNRA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EDNRA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EDNRA/ ET-A/ ETA VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002753 | human EDNRA Lentivirus plasmid |
| ORF Viral Vector | vGMLP002753 | human EDNRA Lentivirus particle |
| ORF Viral Vector | pGMLPm002807 | mouse Ednra Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002807 | mouse Ednra Lentivirus particle |
Target information
| Target ID | GM-T23499 |
| Target Name | EDNRA |
| Gene ID | 1909,13617,24326,704135,450187,101083419,281749,100062644 |
| Gene Symbol and Synonyms | AEA001,EDNRA,Endor,ET-A,ET-AR,ETA,ETA-R,ETAR,ETRA,Gpcr10,hET-AR,MFDA,Mhdaaea1,RGD1559432 |
| Uniprot Accession | P25101,P26684,Q5KSU9,P21450 |
| Uniprot Entry Name | EDNRA_HUMAN,EDNRA_RAT,EDNRA_CANLF,EDNRA_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000151617 |
| Target Classification | GPCR |
The target: EDNRA, gene name: EDNRA, also named as ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR. This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
