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Anti-BKRB2/ BDKRB2/ B2R monoclonal antibody
Anti-BKRB2/ BDKRB2/ B2R antibody for FACS & in-vivo assay
Go to BDKRB2/BDKRB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23714-Ab-1/ GM-Tg-hg-T23714-Ab-2 | Anti-Human BDKRB2 monoclonal antibody | Human |
| GM-Tg-rg-T23714-Ab-1/ GM-Tg-rg-T23714-Ab-2 | Anti-Rat BDKRB2 monoclonal antibody | Rat |
| GM-Tg-mg-T23714-Ab-1/ GM-Tg-mg-T23714-Ab-2 | Anti-Mouse BDKRB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T23714-Ab-1/ GM-Tg-cynog-T23714-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BDKRB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23714-Ab-1/ GM-Tg-felg-T23714-Ab-2 | Anti-Feline BDKRB2 monoclonal antibody | Feline |
| GM-Tg-cang-T23714-Ab-1/ GM-Tg-cang-T23714-Ab-2 | Anti-Canine BDKRB2 monoclonal antibody | Canine |
| GM-Tg-bovg-T23714-Ab-1/ GM-Tg-bovg-T23714-Ab-2 | Anti-Bovine BDKRB2 monoclonal antibody | Bovine |
| GM-Tg-equg-T23714-Ab-1/ GM-Tg-equg-T23714-Ab-2 | Anti-Equine BDKRB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23714-Ab-1/ GM-Tg-hg-T23714-Ab-2; GM-Tg-rg-T23714-Ab-1/ GM-Tg-rg-T23714-Ab-2; GM-Tg-mg-T23714-Ab-1/ GM-Tg-mg-T23714-Ab-2; GM-Tg-cynog-T23714-Ab-1/ GM-Tg-cynog-T23714-Ab-2; GM-Tg-felg-T23714-Ab-1/ GM-Tg-felg-T23714-Ab-2; GM-Tg-cang-T23714-Ab-1/ GM-Tg-cang-T23714-Ab-2; GM-Tg-bovg-T23714-Ab-1/ GM-Tg-bovg-T23714-Ab-2; GM-Tg-equg-T23714-Ab-1/ GM-Tg-equg-T23714-Ab-2 |
| Products Name | Anti-BDKRB2 monoclonal antibody |
| Format | mab |
| Target Name | BDKRB2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BDKRB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species BKRB2/ BDKRB2/ B2R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000226 | mouse Bdkrb2 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000226 | mouse Bdkrb2 Adenovirus particle |
Target information
| Target ID | GM-T23714 |
| Target Name | BDKRB2 |
| Gene ID | 624,12062,25245,703698,538896,100054796 |
| Gene Symbol and Synonyms | B(2),B2,B2BKR,B2BRA,B2R,BDKRB2,BK-2,BK2,BK2R,BKR2,BRB2 |
| Uniprot Accession | P30411,P25023 |
| Uniprot Entry Name | BKRB2_HUMAN,BKRB2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000168398 |
| Target Classification | N/A |
The target: BDKRB2, gene name: BDKRB2, also named as B2R, BK-2, BK2, BKR2, BRB2. This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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