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Anti-IC1/ SERPING1/ C1IN functional antibody
Anti-IC1/ SERPING1/ C1IN functional antibody for cell culture, ELISA & in-vivo assay
Go to SERPING1/SERPING1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T24211-Ab-1/ GM-Tg-hg-T24211-Ab-2 | Anti-Human SERPING1 monoclonal antibody | Human |
| GM-Tg-rg-T24211-Ab-1/ GM-Tg-rg-T24211-Ab-2 | Anti-Rat SERPING1 monoclonal antibody | Rat |
| GM-Tg-mg-T24211-Ab-1/ GM-Tg-mg-T24211-Ab-2 | Anti-Mouse SERPING1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T24211-Ab-1/ GM-Tg-cynog-T24211-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SERPING1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T24211-Ab-1/ GM-Tg-felg-T24211-Ab-2 | Anti-Feline SERPING1 monoclonal antibody | Feline |
| GM-Tg-cang-T24211-Ab-1/ GM-Tg-cang-T24211-Ab-2 | Anti-Canine SERPING1 monoclonal antibody | Canine |
| GM-Tg-bovg-T24211-Ab-1/ GM-Tg-bovg-T24211-Ab-2 | Anti-Bovine SERPING1 monoclonal antibody | Bovine |
| GM-Tg-equg-T24211-Ab-1/ GM-Tg-equg-T24211-Ab-2 | Anti-Equine SERPING1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T24211-Ab-1/ GM-Tg-hg-T24211-Ab-2; GM-Tg-rg-T24211-Ab-1/ GM-Tg-rg-T24211-Ab-2; GM-Tg-mg-T24211-Ab-1/ GM-Tg-mg-T24211-Ab-2; GM-Tg-cynog-T24211-Ab-1/ GM-Tg-cynog-T24211-Ab-2; GM-Tg-felg-T24211-Ab-1/ GM-Tg-felg-T24211-Ab-2; GM-Tg-cang-T24211-Ab-1/ GM-Tg-cang-T24211-Ab-2; GM-Tg-bovg-T24211-Ab-1/ GM-Tg-bovg-T24211-Ab-2; GM-Tg-equg-T24211-Ab-1/ GM-Tg-equg-T24211-Ab-2 |
| Products Name | Anti-SERPING1 monoclonal antibody |
| Format | mab |
| Target Name | SERPING1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SERPING1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T24211-Ag-1 | Recombinant multi-species IC1/ SERPING1/ C1IN protein |
| ORF Viral Vector | pGMLP001061 | human SERPING1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001061 | human SERPING1 Lentivirus particle |
| ORF Viral Vector | pGMLPm004836 | mouse Serping1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004836 | mouse Serping1 Lentivirus particle |
Target information
| Target ID | GM-T24211 |
| Target Name | SERPING1 |
| Gene ID | 710,12258,295703,703928,475966,101087683,281035,100066476 |
| Gene Symbol and Synonyms | C1 Inh,C1-IA,C1IN,C1INH,C1INH.,C1NH,HAE1,HAE2,SERPING1 |
| Uniprot Accession | P05155,Q6P734,P50448 |
| Uniprot Entry Name | IC1_HUMAN,IC1_RAT,F12AI_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000149131 |
| Target Classification | N/A |
The target: SERPING1, gene name: SERPING1, also named as C1IN, C1INH, C1NH, HAE1, HAE2. This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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