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Anti-LICH/ LIPA/ CESD functional antibody
Anti-LICH/ LIPA/ CESD functional antibody for cell culture, ELISA & in-vivo assay
Go to LIPA/LIPA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T24373-Ab-1/ GM-Tg-hg-T24373-Ab-2 | Anti-Human LIPA monoclonal antibody | Human |
| GM-Tg-rg-T24373-Ab-1/ GM-Tg-rg-T24373-Ab-2 | Anti-Rat LIPA monoclonal antibody | Rat |
| GM-Tg-mg-T24373-Ab-1/ GM-Tg-mg-T24373-Ab-2 | Anti-Mouse LIPA monoclonal antibody | Mouse |
| GM-Tg-cynog-T24373-Ab-1/ GM-Tg-cynog-T24373-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LIPA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T24373-Ab-1/ GM-Tg-felg-T24373-Ab-2 | Anti-Feline LIPA monoclonal antibody | Feline |
| GM-Tg-cang-T24373-Ab-1/ GM-Tg-cang-T24373-Ab-2 | Anti-Canine LIPA monoclonal antibody | Canine |
| GM-Tg-bovg-T24373-Ab-1/ GM-Tg-bovg-T24373-Ab-2 | Anti-Bovine LIPA monoclonal antibody | Bovine |
| GM-Tg-equg-T24373-Ab-1/ GM-Tg-equg-T24373-Ab-2 | Anti-Equine LIPA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T24373-Ab-1/ GM-Tg-hg-T24373-Ab-2; GM-Tg-rg-T24373-Ab-1/ GM-Tg-rg-T24373-Ab-2; GM-Tg-mg-T24373-Ab-1/ GM-Tg-mg-T24373-Ab-2; GM-Tg-cynog-T24373-Ab-1/ GM-Tg-cynog-T24373-Ab-2; GM-Tg-felg-T24373-Ab-1/ GM-Tg-felg-T24373-Ab-2; GM-Tg-cang-T24373-Ab-1/ GM-Tg-cang-T24373-Ab-2; GM-Tg-bovg-T24373-Ab-1/ GM-Tg-bovg-T24373-Ab-2; GM-Tg-equg-T24373-Ab-1/ GM-Tg-equg-T24373-Ab-2 |
| Products Name | Anti-LIPA monoclonal antibody |
| Format | mab |
| Target Name | LIPA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LIPA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T24373-Ag-1 | Recombinant multi-species LICH/ LIPA/ CESD protein |
| ORF Viral Vector | vGMLP002961 | human LIPA Lentivirus particle |
| ORF Viral Vector | pGMLP002961 | human LIPA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004929 | mouse Lipa Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004929 | mouse Lipa Lentivirus particle |
Target information
| Target ID | GM-T24373 |
| Target Name | LIPA |
| Gene ID | 3988,16889,25055,695240,100856363,101094134,100125267,100071626 |
| Gene Symbol and Synonyms | CESD,Chole,Chole2,LAL,Lip-1,Lip1,LIPA |
| Uniprot Accession | P38571,Q64194 |
| Uniprot Entry Name | LICH_HUMAN,LICH_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000107798 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LIPA, gene name: LIPA, also named as CESD, LAL. This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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