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Anti-DRD4/ D4R/ D4DR monoclonal antibody
Anti-DRD4/ D4R/ D4DR antibody for FACS & in-vivo assay
Go to D4R/DRD4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T24983-Ab-1/ GM-Tg-hg-T24983-Ab-2 | Anti-Human D4R/DRD4 monoclonal antibody | Human |
| GM-Tg-rg-T24983-Ab-1/ GM-Tg-rg-T24983-Ab-2 | Anti-Rat D4R/DRD4 monoclonal antibody | Rat |
| GM-Tg-mg-T24983-Ab-1/ GM-Tg-mg-T24983-Ab-2 | Anti-Mouse D4R/DRD4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T24983-Ab-1/ GM-Tg-cynog-T24983-Ab-2 | Anti-Cynomolgus/ Rhesus macaque D4R/DRD4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T24983-Ab-1/ GM-Tg-felg-T24983-Ab-2 | Anti-Feline D4R/DRD4 monoclonal antibody | Feline |
| GM-Tg-cang-T24983-Ab-1/ GM-Tg-cang-T24983-Ab-2 | Anti-Canine D4R/DRD4 monoclonal antibody | Canine |
| GM-Tg-bovg-T24983-Ab-1/ GM-Tg-bovg-T24983-Ab-2 | Anti-Bovine D4R/DRD4 monoclonal antibody | Bovine |
| GM-Tg-equg-T24983-Ab-1/ GM-Tg-equg-T24983-Ab-2 | Anti-Equine D4R/DRD4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T24983-Ab-1/ GM-Tg-hg-T24983-Ab-2; GM-Tg-rg-T24983-Ab-1/ GM-Tg-rg-T24983-Ab-2; GM-Tg-mg-T24983-Ab-1/ GM-Tg-mg-T24983-Ab-2; GM-Tg-cynog-T24983-Ab-1/ GM-Tg-cynog-T24983-Ab-2; GM-Tg-felg-T24983-Ab-1/ GM-Tg-felg-T24983-Ab-2; GM-Tg-cang-T24983-Ab-1/ GM-Tg-cang-T24983-Ab-2; GM-Tg-bovg-T24983-Ab-1/ GM-Tg-bovg-T24983-Ab-2; GM-Tg-equg-T24983-Ab-1/ GM-Tg-equg-T24983-Ab-2 |
| Products Name | Anti-D4R/DRD4 monoclonal antibody |
| Format | mab |
| Target Name | D4R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-D4R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DRD4/ D4R/ D4DR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003674 | human DRD4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003674 | human DRD4 Lentivirus particle |
| ORF Viral Vector | pGMLPm002528 | mouse Drd4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002528 | mouse Drd4 Lentivirus particle |
Target information
| Target ID | GM-T24983 |
| Target Name | D4R |
| Gene ID | 1815,13491,25432,699697,119864199,111556768,101906668,100147552 |
| Gene Symbol and Synonyms | D4DR,D4R,D4RA,Drd-4,DRD4 |
| Uniprot Accession | P21917,P30729 |
| Uniprot Entry Name | DRD4_HUMAN,DRD4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000069696 |
| Target Classification | N/A |
The target: D4R, gene name: DRD4, also named as D4DR. This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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