Anti-MDR1/ ABCB1/ ABC20 monoclonal antibody

Anti-MDR1/ ABCB1/ ABC20 antibody for FACS & in-vivo assay

Target products collectionGo to ABCB1/ABCB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T25258-Ab-1/ GM-Tg-hg-T25258-Ab-2Anti-Human ABCB1 monoclonal antibodyHuman
GM-Tg-rg-T25258-Ab-1/ GM-Tg-rg-T25258-Ab-2Anti-Rat ABCB1 monoclonal antibodyRat
GM-Tg-mg-T25258-Ab-1/ GM-Tg-mg-T25258-Ab-2Anti-Mouse ABCB1 monoclonal antibodyMouse
GM-Tg-cynog-T25258-Ab-1/ GM-Tg-cynog-T25258-Ab-2Anti-Cynomolgus/ Rhesus macaque ABCB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T25258-Ab-1/ GM-Tg-felg-T25258-Ab-2Anti-Feline ABCB1 monoclonal antibodyFeline
GM-Tg-cang-T25258-Ab-1/ GM-Tg-cang-T25258-Ab-2Anti-Canine ABCB1 monoclonal antibodyCanine
GM-Tg-bovg-T25258-Ab-1/ GM-Tg-bovg-T25258-Ab-2Anti-Bovine ABCB1 monoclonal antibodyBovine
GM-Tg-equg-T25258-Ab-1/ GM-Tg-equg-T25258-Ab-2Anti-Equine ABCB1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-T25258-Ab-1/ GM-Tg-hg-T25258-Ab-2; GM-Tg-rg-T25258-Ab-1/ GM-Tg-rg-T25258-Ab-2;
GM-Tg-mg-T25258-Ab-1/ GM-Tg-mg-T25258-Ab-2; GM-Tg-cynog-T25258-Ab-1/ GM-Tg-cynog-T25258-Ab-2;
GM-Tg-felg-T25258-Ab-1/ GM-Tg-felg-T25258-Ab-2; GM-Tg-cang-T25258-Ab-1/ GM-Tg-cang-T25258-Ab-2;
GM-Tg-bovg-T25258-Ab-1/ GM-Tg-bovg-T25258-Ab-2; GM-Tg-equg-T25258-Ab-1/ GM-Tg-equg-T25258-Ab-2
Products NameAnti-ABCB1 monoclonal antibody
Target NameABCB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-ABCB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

    Click to get more Data / Case study about the product.

    Associated products

    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MDR1/ ABCB1/ ABC20 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000440human ABCB1 Lentivirus particle
    ORF Viral VectorpGMLV000440human ABCB1 Lentivirus plasmid

    Target information

    Target IDGM-T25258
    Target NameABCB1
    Gene ID5243,18669,574235,403879,493707,100034074
    Gene Symbol and SynonymsABC20,ABCB1,Abcb1b,CD243,CLCS,GP170,mdr,MDR1,Mdr1b,p-170,P-GP,Pgy-1,PGY1
    Uniprot AccessionP08183
    Uniprot Entry NameMDR1_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    Gene EnsemblENSG00000085563
    Target ClassificationTumor-associated antigen (TAA)

    The target: ABCB1, gene name: ABCB1, also named as ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.