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Anti-PPIB/ B/ CYP-S1 functional antibody
Anti-PPIB/ B/ CYP-S1 functional antibody for cell culture, ELISA & in-vivo assay
Go to PPIB/PPIB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T25847-Ab-1/ GM-Tg-hg-T25847-Ab-2 | Anti-Human PPIB monoclonal antibody | Human |
| GM-Tg-rg-T25847-Ab-1/ GM-Tg-rg-T25847-Ab-2 | Anti-Rat PPIB monoclonal antibody | Rat |
| GM-Tg-mg-T25847-Ab-1/ GM-Tg-mg-T25847-Ab-2 | Anti-Mouse PPIB monoclonal antibody | Mouse |
| GM-Tg-cynog-T25847-Ab-1/ GM-Tg-cynog-T25847-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPIB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T25847-Ab-1/ GM-Tg-felg-T25847-Ab-2 | Anti-Feline PPIB monoclonal antibody | Feline |
| GM-Tg-cang-T25847-Ab-1/ GM-Tg-cang-T25847-Ab-2 | Anti-Canine PPIB monoclonal antibody | Canine |
| GM-Tg-bovg-T25847-Ab-1/ GM-Tg-bovg-T25847-Ab-2 | Anti-Bovine PPIB monoclonal antibody | Bovine |
| GM-Tg-equg-T25847-Ab-1/ GM-Tg-equg-T25847-Ab-2 | Anti-Equine PPIB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T25847-Ab-1/ GM-Tg-hg-T25847-Ab-2; GM-Tg-rg-T25847-Ab-1/ GM-Tg-rg-T25847-Ab-2; GM-Tg-mg-T25847-Ab-1/ GM-Tg-mg-T25847-Ab-2; GM-Tg-cynog-T25847-Ab-1/ GM-Tg-cynog-T25847-Ab-2; GM-Tg-felg-T25847-Ab-1/ GM-Tg-felg-T25847-Ab-2; GM-Tg-cang-T25847-Ab-1/ GM-Tg-cang-T25847-Ab-2; GM-Tg-bovg-T25847-Ab-1/ GM-Tg-bovg-T25847-Ab-2; GM-Tg-equg-T25847-Ab-1/ GM-Tg-equg-T25847-Ab-2 |
| Products Name | Anti-PPIB monoclonal antibody |
| Format | mab |
| Target Name | PPIB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PPIB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T25847-Ag-1 | Recombinant multi-species PPIB/ B/ CYP-S1 protein |
| ORF Viral Vector | vGMLP002164 | human PPIB Lentivirus particle |
| ORF Viral Vector | pGMLP002164 | human PPIB Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003716 | mouse Ppib Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003716 | mouse Ppib Lentivirus particle |
Target information
| Target ID | GM-T25847 |
| Target Name | PPIB |
| Gene ID | 5479,19035,64367,706757,478337,101087581,281419,100066834 |
| Gene Symbol and Synonyms | Cphn-2,Cphn2,CyP-20b,CYP-S1,CYPB,HEL-S-39,OI9,PPIB,SCYLP |
| Uniprot Accession | P23284,P24368,P80311 |
| Uniprot Entry Name | PPIB_HUMAN,PPIB_RAT,PPIB_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000166794 |
| Target Classification | N/A |
The target: PPIB, gene name: PPIB, also named as B, CYP-S1, CYPB, HEL-S-39, OI9, SCYLP. The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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