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Anti-AKR1B1 monoclonal antibody
Pre-made anti-AKR1B1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to AKR1B1/AKR1B1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T26623-Ab-1/ GM-Tg-hg-T26623-Ab-2 | Anti-Human AKR1B1 monoclonal antibody | Human |
| GM-Tg-rg-T26623-Ab-1/ GM-Tg-rg-T26623-Ab-2 | Anti-Rat AKR1B1 monoclonal antibody | Rat |
| GM-Tg-mg-T26623-Ab-1/ GM-Tg-mg-T26623-Ab-2 | Anti-Mouse AKR1B1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T26623-Ab-1/ GM-Tg-cynog-T26623-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AKR1B1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T26623-Ab-1/ GM-Tg-felg-T26623-Ab-2 | Anti-Feline AKR1B1 monoclonal antibody | Feline |
| GM-Tg-cang-T26623-Ab-1/ GM-Tg-cang-T26623-Ab-2 | Anti-Canine AKR1B1 monoclonal antibody | Canine |
| GM-Tg-bovg-T26623-Ab-1/ GM-Tg-bovg-T26623-Ab-2 | Anti-Bovine AKR1B1 monoclonal antibody | Bovine |
| GM-Tg-equg-T26623-Ab-1/ GM-Tg-equg-T26623-Ab-2 | Anti-Equine AKR1B1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T26623-Ab-1/ GM-Tg-hg-T26623-Ab-2; GM-Tg-rg-T26623-Ab-1/ GM-Tg-rg-T26623-Ab-2; GM-Tg-mg-T26623-Ab-1/ GM-Tg-mg-T26623-Ab-2; GM-Tg-cynog-T26623-Ab-1/ GM-Tg-cynog-T26623-Ab-2; GM-Tg-felg-T26623-Ab-1/ GM-Tg-felg-T26623-Ab-2; GM-Tg-cang-T26623-Ab-1/ GM-Tg-cang-T26623-Ab-2; GM-Tg-bovg-T26623-Ab-1/ GM-Tg-bovg-T26623-Ab-2; GM-Tg-equg-T26623-Ab-1/ GM-Tg-equg-T26623-Ab-2 |
| Products Name | Anti-AKR1B1 monoclonal antibody |
| Format | mab |
| Target Name | AKR1B1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-AKR1B1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T26623-Ag-1 | Recombinant multi-species ALDR/ AKR1B1/ ADR protein |
| ORF Viral Vector | pGMLP000471 | human AKR1B1 Lentivirus plasmid |
| ORF Viral Vector | pGMAP000366 | Human AKR1B1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000366 | Human AKR1B1 Adenovirus particle |
| ORF Viral Vector | vGMLP000471 | human AKR1B1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000822 | mouse Akr1b3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000822 | mouse Akr1b3 Lentivirus particle |
Target information
| Target ID | GM-T26623 |
| Target Name | AKR1B1 |
| Gene ID | 231,11677,607537,101095406,100065145 |
| Gene Symbol and Synonyms | ADR,Ahr-1,Ahr1,AKR1B1,Akr1b3,Aldor1,ALDR1,ALR2,AR |
| Uniprot Accession | P15121 |
| Uniprot Entry Name | ALDR_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000085662 |
| Target Classification | N/A |
The target: AKR1B1, gene name: AKR1B1, also named as ADR, ALDR1, ALR2, AR. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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