Anti-GBRD/ GABRD/ EIG10 monoclonal antibody

Anti-GBRD/ GABRD/ EIG10 antibody for FACS & in-vivo assay

Target products collectionGo to GABRD/GABRD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T27376-Ab-1/ GM-Tg-hg-T27376-Ab-2Anti-Human GABRD monoclonal antibodyHuman
GM-Tg-rg-T27376-Ab-1/ GM-Tg-rg-T27376-Ab-2Anti-Rat GABRD monoclonal antibodyRat
GM-Tg-mg-T27376-Ab-1/ GM-Tg-mg-T27376-Ab-2Anti-Mouse GABRD monoclonal antibodyMouse
GM-Tg-cynog-T27376-Ab-1/ GM-Tg-cynog-T27376-Ab-2Anti-Cynomolgus/ Rhesus macaque GABRD monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T27376-Ab-1/ GM-Tg-felg-T27376-Ab-2Anti-Feline GABRD monoclonal antibodyFeline
GM-Tg-cang-T27376-Ab-1/ GM-Tg-cang-T27376-Ab-2Anti-Canine GABRD monoclonal antibodyCanine
GM-Tg-bovg-T27376-Ab-1/ GM-Tg-bovg-T27376-Ab-2Anti-Bovine GABRD monoclonal antibodyBovine
GM-Tg-equg-T27376-Ab-1/ GM-Tg-equg-T27376-Ab-2Anti-Equine GABRD monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T27376-Ab-1/ GM-Tg-hg-T27376-Ab-2; GM-Tg-rg-T27376-Ab-1/ GM-Tg-rg-T27376-Ab-2;
GM-Tg-mg-T27376-Ab-1/ GM-Tg-mg-T27376-Ab-2; GM-Tg-cynog-T27376-Ab-1/ GM-Tg-cynog-T27376-Ab-2;
GM-Tg-felg-T27376-Ab-1/ GM-Tg-felg-T27376-Ab-2; GM-Tg-cang-T27376-Ab-1/ GM-Tg-cang-T27376-Ab-2;
GM-Tg-bovg-T27376-Ab-1/ GM-Tg-bovg-T27376-Ab-2; GM-Tg-equg-T27376-Ab-1/ GM-Tg-equg-T27376-Ab-2
Products NameAnti-GABRD monoclonal antibody
Formatmab
Target NameGABRD
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GABRD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GBRD/ GABRD/ EIG10 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP004093human GABRD Lentivirus particle
    ORF Viral VectorpGMLP004093human GABRD Lentivirus plasmid
    ORF Viral VectorvGMLP003715human GABRD Lentivirus particle
    ORF Viral VectorpGMLP003715human GABRD Lentivirus plasmid
    ORF Viral VectorpGMLPm004340mouse Gabrd Lentivirus plasmid
    ORF Viral VectorvGMLPm004340mouse Gabrd Lentivirus particle


    Target information

    Target IDGM-T27376
    Target NameGABRD
    Gene ID2563,14403,29689,710062,489609,101087589,508711,100064300
    Gene Symbol and SynonymsEIG10,EJM7,GABAA-RD,GABRD,GEFSP5
    Uniprot AccessionO14764,P18506
    Uniprot Entry NameGBRD_HUMAN,GBRD_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000187730
    Target ClassificationN/A

    The target: GABRD, gene name: GABRD, also named as EIG10, EJM7, GEFSP5. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.