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Anti-GBRD/ GABRD/ EIG10 monoclonal antibody
Anti-GBRD/ GABRD/ EIG10 antibody for FACS & in-vivo assay
Go to GABRD/GABRD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T27376-Ab-1/ GM-Tg-hg-T27376-Ab-2 | Anti-Human GABRD monoclonal antibody | Human |
| GM-Tg-rg-T27376-Ab-1/ GM-Tg-rg-T27376-Ab-2 | Anti-Rat GABRD monoclonal antibody | Rat |
| GM-Tg-mg-T27376-Ab-1/ GM-Tg-mg-T27376-Ab-2 | Anti-Mouse GABRD monoclonal antibody | Mouse |
| GM-Tg-cynog-T27376-Ab-1/ GM-Tg-cynog-T27376-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GABRD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T27376-Ab-1/ GM-Tg-felg-T27376-Ab-2 | Anti-Feline GABRD monoclonal antibody | Feline |
| GM-Tg-cang-T27376-Ab-1/ GM-Tg-cang-T27376-Ab-2 | Anti-Canine GABRD monoclonal antibody | Canine |
| GM-Tg-bovg-T27376-Ab-1/ GM-Tg-bovg-T27376-Ab-2 | Anti-Bovine GABRD monoclonal antibody | Bovine |
| GM-Tg-equg-T27376-Ab-1/ GM-Tg-equg-T27376-Ab-2 | Anti-Equine GABRD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T27376-Ab-1/ GM-Tg-hg-T27376-Ab-2; GM-Tg-rg-T27376-Ab-1/ GM-Tg-rg-T27376-Ab-2; GM-Tg-mg-T27376-Ab-1/ GM-Tg-mg-T27376-Ab-2; GM-Tg-cynog-T27376-Ab-1/ GM-Tg-cynog-T27376-Ab-2; GM-Tg-felg-T27376-Ab-1/ GM-Tg-felg-T27376-Ab-2; GM-Tg-cang-T27376-Ab-1/ GM-Tg-cang-T27376-Ab-2; GM-Tg-bovg-T27376-Ab-1/ GM-Tg-bovg-T27376-Ab-2; GM-Tg-equg-T27376-Ab-1/ GM-Tg-equg-T27376-Ab-2 |
| Products Name | Anti-GABRD monoclonal antibody |
| Format | mab |
| Target Name | GABRD |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GABRD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GBRD/ GABRD/ EIG10 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004093 | human GABRD Lentivirus particle |
| ORF Viral Vector | pGMLP004093 | human GABRD Lentivirus plasmid |
| ORF Viral Vector | vGMLP003715 | human GABRD Lentivirus particle |
| ORF Viral Vector | pGMLP003715 | human GABRD Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004340 | mouse Gabrd Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004340 | mouse Gabrd Lentivirus particle |
Target information
| Target ID | GM-T27376 |
| Target Name | GABRD |
| Gene ID | 2563,14403,29689,710062,489609,101087589,508711,100064300 |
| Gene Symbol and Synonyms | EIG10,EJM7,GABAA-RD,GABRD,GEFSP5 |
| Uniprot Accession | O14764,P18506 |
| Uniprot Entry Name | GBRD_HUMAN,GBRD_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000187730 |
| Target Classification | N/A |
The target: GABRD, gene name: GABRD, also named as EIG10, EJM7, GEFSP5. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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