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Anti-SC6A4/ SERT/ SLC6A4 monoclonal antibody
Anti-SC6A4/ SERT/ SLC6A4 antibody for FACS & in-vivo assay
Go to SERT/SLC6A4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T27812-Ab-1/ GM-Tg-hg-T27812-Ab-2 | Anti-Human SERT/SLC6A4 monoclonal antibody | Human |
| GM-Tg-rg-T27812-Ab-1/ GM-Tg-rg-T27812-Ab-2 | Anti-Rat SERT/SLC6A4 monoclonal antibody | Rat |
| GM-Tg-mg-T27812-Ab-1/ GM-Tg-mg-T27812-Ab-2 | Anti-Mouse SERT/SLC6A4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T27812-Ab-1/ GM-Tg-cynog-T27812-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SERT/SLC6A4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T27812-Ab-1/ GM-Tg-felg-T27812-Ab-2 | Anti-Feline SERT/SLC6A4 monoclonal antibody | Feline |
| GM-Tg-cang-T27812-Ab-1/ GM-Tg-cang-T27812-Ab-2 | Anti-Canine SERT/SLC6A4 monoclonal antibody | Canine |
| GM-Tg-bovg-T27812-Ab-1/ GM-Tg-bovg-T27812-Ab-2 | Anti-Bovine SERT/SLC6A4 monoclonal antibody | Bovine |
| GM-Tg-equg-T27812-Ab-1/ GM-Tg-equg-T27812-Ab-2 | Anti-Equine SERT/SLC6A4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T27812-Ab-1/ GM-Tg-hg-T27812-Ab-2; GM-Tg-rg-T27812-Ab-1/ GM-Tg-rg-T27812-Ab-2; GM-Tg-mg-T27812-Ab-1/ GM-Tg-mg-T27812-Ab-2; GM-Tg-cynog-T27812-Ab-1/ GM-Tg-cynog-T27812-Ab-2; GM-Tg-felg-T27812-Ab-1/ GM-Tg-felg-T27812-Ab-2; GM-Tg-cang-T27812-Ab-1/ GM-Tg-cang-T27812-Ab-2; GM-Tg-bovg-T27812-Ab-1/ GM-Tg-bovg-T27812-Ab-2; GM-Tg-equg-T27812-Ab-1/ GM-Tg-equg-T27812-Ab-2 |
| Products Name | Anti-SERT/SLC6A4 monoclonal antibody |
| Format | mab |
| Target Name | SERT |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SERT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SC6A4/ SERT/ SLC6A4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm004040 | mouse Slc6a4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004040 | mouse Slc6a4 Lentivirus particle |
Target information
| Target ID | GM-T27812 |
| Target Name | SERT |
| Gene ID | 6532,15567,25553,574140,491184,101091163,282365,100033848 |
| Gene Symbol and Synonyms | 5-HTT,5-HTTLPR,5HTT,hSERT,HTT,OCD1,SERT,SERT1,SLC6A4 |
| Uniprot Accession | P31645,P31652,Q9MYX0,Q9XT49 |
| Uniprot Entry Name | SC6A4_HUMAN,SC6A4_MACMU,SC6A4_RAT,SC6A4_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Autistic disorder |
| Gene Ensembl | ENSG00000108576 |
| Target Classification | N/A |
The target: SERT, gene name: SLC6A4, also named as 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT. This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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