Anti-A1AT/ SERPINA1/ A1A functional antibody

Anti-A1AT/ SERPINA1/ A1A functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SERPINA1/SERPINA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T28265-Ab-1/ GM-Tg-hg-T28265-Ab-2Anti-Human SERPINA1 monoclonal antibodyHuman
GM-Tg-rg-T28265-Ab-1/ GM-Tg-rg-T28265-Ab-2Anti-Rat SERPINA1 monoclonal antibodyRat
GM-Tg-mg-T28265-Ab-1/ GM-Tg-mg-T28265-Ab-2Anti-Mouse SERPINA1 monoclonal antibodyMouse
GM-Tg-cynog-T28265-Ab-1/ GM-Tg-cynog-T28265-Ab-2Anti-Cynomolgus/ Rhesus macaque SERPINA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T28265-Ab-1/ GM-Tg-felg-T28265-Ab-2Anti-Feline SERPINA1 monoclonal antibodyFeline
GM-Tg-cang-T28265-Ab-1/ GM-Tg-cang-T28265-Ab-2Anti-Canine SERPINA1 monoclonal antibodyCanine
GM-Tg-bovg-T28265-Ab-1/ GM-Tg-bovg-T28265-Ab-2Anti-Bovine SERPINA1 monoclonal antibodyBovine
GM-Tg-equg-T28265-Ab-1/ GM-Tg-equg-T28265-Ab-2Anti-Equine SERPINA1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-T28265-Ab-1/ GM-Tg-hg-T28265-Ab-2; GM-Tg-rg-T28265-Ab-1/ GM-Tg-rg-T28265-Ab-2;
GM-Tg-mg-T28265-Ab-1/ GM-Tg-mg-T28265-Ab-2; GM-Tg-cynog-T28265-Ab-1/ GM-Tg-cynog-T28265-Ab-2;
GM-Tg-felg-T28265-Ab-1/ GM-Tg-felg-T28265-Ab-2; GM-Tg-cang-T28265-Ab-1/ GM-Tg-cang-T28265-Ab-2;
GM-Tg-bovg-T28265-Ab-1/ GM-Tg-bovg-T28265-Ab-2; GM-Tg-equg-T28265-Ab-1/ GM-Tg-equg-T28265-Ab-2
Products NameAnti-SERPINA1 monoclonal antibody
Target NameSERPINA1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-SERPINA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

    Click to get more Data / Case study about the product.

    Associated products

    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T28265-Ag-1Recombinant multi-species A1AT/ SERPINA1/ A1A protein
    ORF Viral VectorvGMLP003894human SERPINA1 Lentivirus particle
    ORF Viral VectorpGMLP003894human SERPINA1 Lentivirus plasmid
    ORF Viral VectorvGMAP000441Human SERPINA1 Adenovirus particle
    ORF Viral VectorpGMAP000441Human SERPINA1 Adenovirus plasmid
    ORF Viral VectorpGMAAV000168human SERPINA1 AAV plasmid
    ORF Viral VectorvGMAAV000168human SERPINA1 AAV particle
    ORF Viral VectorpGMLPm003774mouse Serpina1c Lentivirus plasmid
    ORF Viral VectorvGMLPm003774mouse Serpina1c Lentivirus particle

    Target information

    Target IDGM-T28265
    Target NameSERPINA1
    Gene ID5265,701361,280699
    Gene Symbol and SynonymsA1A,A1AT,AAT,alpha1AT,nNIF,PI,PI1,PRO2275,SERPINA1
    Uniprot AccessionP01009,P34955
    Uniprot Entry NameA1AT_HUMAN,A1AT_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target
    DiseaseMalignant neoplasm of bladder, IgA glomerulonephritis, Nephrotic syndrome with focal and segmental glomerular lesions, Diabetic Nephropathy, Contrast - Induced Nephropathy, Congenital occlusion of ureteropelvic junction, Calculus of kidney, Nephrotic syndrome, Acute pancreatitis, Juvenile arthritis, Urinary bladder urothelial carcinoma, Type 2 diabetes mellitus with diabetic nephropathy, protease
    Gene EnsemblENSG00000197249
    Target ClassificationN/A

    The target: SERPINA1, gene name: SERPINA1, also named as A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF. The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.