Anti-GBRG3/ GABRG3 monoclonal antibody

Anti-GBRG3/ GABRG3 antibody for FACS & in-vivo assay

Target products collectionGo to GABRG3/GABRG3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T28722-Ab-1/ GM-Tg-hg-T28722-Ab-2Anti-Human GABRG3 monoclonal antibodyHuman
GM-Tg-rg-T28722-Ab-1/ GM-Tg-rg-T28722-Ab-2Anti-Rat GABRG3 monoclonal antibodyRat
GM-Tg-mg-T28722-Ab-1/ GM-Tg-mg-T28722-Ab-2Anti-Mouse GABRG3 monoclonal antibodyMouse
GM-Tg-cynog-T28722-Ab-1/ GM-Tg-cynog-T28722-Ab-2Anti-Cynomolgus/ Rhesus macaque GABRG3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T28722-Ab-1/ GM-Tg-felg-T28722-Ab-2Anti-Feline GABRG3 monoclonal antibodyFeline
GM-Tg-cang-T28722-Ab-1/ GM-Tg-cang-T28722-Ab-2Anti-Canine GABRG3 monoclonal antibodyCanine
GM-Tg-bovg-T28722-Ab-1/ GM-Tg-bovg-T28722-Ab-2Anti-Bovine GABRG3 monoclonal antibodyBovine
GM-Tg-equg-T28722-Ab-1/ GM-Tg-equg-T28722-Ab-2Anti-Equine GABRG3 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T28722-Ab-1/ GM-Tg-hg-T28722-Ab-2; GM-Tg-rg-T28722-Ab-1/ GM-Tg-rg-T28722-Ab-2;
GM-Tg-mg-T28722-Ab-1/ GM-Tg-mg-T28722-Ab-2; GM-Tg-cynog-T28722-Ab-1/ GM-Tg-cynog-T28722-Ab-2;
GM-Tg-felg-T28722-Ab-1/ GM-Tg-felg-T28722-Ab-2; GM-Tg-cang-T28722-Ab-1/ GM-Tg-cang-T28722-Ab-2;
GM-Tg-bovg-T28722-Ab-1/ GM-Tg-bovg-T28722-Ab-2; GM-Tg-equg-T28722-Ab-1/ GM-Tg-equg-T28722-Ab-2
Products NameAnti-GABRG3 monoclonal antibody
Formatmab
Target NameGABRG3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GABRG3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GBRG3/ GABRG3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T28722
    Target NameGABRG3
    Gene ID2567,14407,79211,720390,488685,101094182,613670,100062806
    Gene Symbol and Synonyms6330406O05Rik,B230362M20Rik,Gabrg-3,GABRG3
    Uniprot AccessionQ99928,P28473
    Uniprot Entry NameGBRG3_HUMAN,GBRG3_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000182256
    Target ClassificationN/A

    The target: GABRG3, gene name: GABRG3, also named as . This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene..



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.