Anti-ADA1B/ ADRA1B/ ADRA1 monoclonal antibody

Anti-ADA1B/ ADRA1B/ ADRA1 antibody for FACS & in-vivo assay

Target products collectionGo to ADRA1B/ADRA1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T29500-Ab-1/ GM-Tg-hg-T29500-Ab-2Anti-Human ADRA1B monoclonal antibodyHuman
GM-Tg-rg-T29500-Ab-1/ GM-Tg-rg-T29500-Ab-2Anti-Rat ADRA1B monoclonal antibodyRat
GM-Tg-mg-T29500-Ab-1/ GM-Tg-mg-T29500-Ab-2Anti-Mouse ADRA1B monoclonal antibodyMouse
GM-Tg-cynog-T29500-Ab-1/ GM-Tg-cynog-T29500-Ab-2Anti-Cynomolgus/ Rhesus macaque ADRA1B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T29500-Ab-1/ GM-Tg-felg-T29500-Ab-2Anti-Feline ADRA1B monoclonal antibodyFeline
GM-Tg-cang-T29500-Ab-1/ GM-Tg-cang-T29500-Ab-2Anti-Canine ADRA1B monoclonal antibodyCanine
GM-Tg-bovg-T29500-Ab-1/ GM-Tg-bovg-T29500-Ab-2Anti-Bovine ADRA1B monoclonal antibodyBovine
GM-Tg-equg-T29500-Ab-1/ GM-Tg-equg-T29500-Ab-2Anti-Equine ADRA1B monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T29500-Ab-1/ GM-Tg-hg-T29500-Ab-2; GM-Tg-rg-T29500-Ab-1/ GM-Tg-rg-T29500-Ab-2;
GM-Tg-mg-T29500-Ab-1/ GM-Tg-mg-T29500-Ab-2; GM-Tg-cynog-T29500-Ab-1/ GM-Tg-cynog-T29500-Ab-2;
GM-Tg-felg-T29500-Ab-1/ GM-Tg-felg-T29500-Ab-2; GM-Tg-cang-T29500-Ab-1/ GM-Tg-cang-T29500-Ab-2;
GM-Tg-bovg-T29500-Ab-1/ GM-Tg-bovg-T29500-Ab-2; GM-Tg-equg-T29500-Ab-1/ GM-Tg-equg-T29500-Ab-2
Products NameAnti-ADRA1B monoclonal antibody
Formatmab
Target NameADRA1B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ADRA1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ADA1B/ ADRA1B/ ADRA1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm005344mouse Adra1b Lentivirus plasmid
    ORF Viral VectorvGMLPm005344mouse Adra1b Lentivirus particle


    Target information

    Target IDGM-T29500
    Target NameADRA1B
    Gene ID147,11548,24173,695106,403962,101092238,407140,100071055
    Gene Symbol and SynonymsADRA1,ADRA1B,ALPHA1BAR,RDC5,[a]1b
    Uniprot AccessionP35368,P15823,P11615
    Uniprot Entry NameADA1B_HUMAN,ADA1B_RAT,ADA1B_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000170214
    Target ClassificationGPCR

    The target: ADRA1B, gene name: ADRA1B, also named as ADRA1, ALPHA1BAR. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.