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Anti-VEGFB/ VEGFL/ VRF functional antibody
Anti-VEGFB/ VEGFL/ VRF functional antibody for cell culture, ELISA & in-vivo assay
Go to VEGFB/VEGFB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30040-Ab-1/ GM-Tg-hg-T30040-Ab-2 | Anti-Human VEGFB monoclonal antibody | Human |
| GM-Tg-rg-T30040-Ab-1/ GM-Tg-rg-T30040-Ab-2 | Anti-Rat VEGFB monoclonal antibody | Rat |
| GM-Tg-mg-T30040-Ab-1/ GM-Tg-mg-T30040-Ab-2 | Anti-Mouse VEGFB monoclonal antibody | Mouse |
| GM-Tg-cynog-T30040-Ab-1/ GM-Tg-cynog-T30040-Ab-2 | Anti-Cynomolgus/ Rhesus macaque VEGFB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30040-Ab-1/ GM-Tg-felg-T30040-Ab-2 | Anti-Feline VEGFB monoclonal antibody | Feline |
| GM-Tg-cang-T30040-Ab-1/ GM-Tg-cang-T30040-Ab-2 | Anti-Canine VEGFB monoclonal antibody | Canine |
| GM-Tg-bovg-T30040-Ab-1/ GM-Tg-bovg-T30040-Ab-2 | Anti-Bovine VEGFB monoclonal antibody | Bovine |
| GM-Tg-equg-T30040-Ab-1/ GM-Tg-equg-T30040-Ab-2 | Anti-Equine VEGFB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30040-Ab-1/ GM-Tg-hg-T30040-Ab-2; GM-Tg-rg-T30040-Ab-1/ GM-Tg-rg-T30040-Ab-2; GM-Tg-mg-T30040-Ab-1/ GM-Tg-mg-T30040-Ab-2; GM-Tg-cynog-T30040-Ab-1/ GM-Tg-cynog-T30040-Ab-2; GM-Tg-felg-T30040-Ab-1/ GM-Tg-felg-T30040-Ab-2; GM-Tg-cang-T30040-Ab-1/ GM-Tg-cang-T30040-Ab-2; GM-Tg-bovg-T30040-Ab-1/ GM-Tg-bovg-T30040-Ab-2; GM-Tg-equg-T30040-Ab-1/ GM-Tg-equg-T30040-Ab-2 |
| Products Name | Anti-VEGFB monoclonal antibody |
| Format | mab |
| Target Name | VEGFB |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-VEGFB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T30040-Ag-1 | Recombinant multi-species VEGFB/ VEGFL/ VRF protein |
| Cytokine | GM-Tg-g-T30040-Ag-1 | Vascular endothelial growth factor B (VEGFB) protein |
| ORF Viral Vector | vGMLP000756 | human VEGFB Lentivirus particle |
| ORF Viral Vector | pGMLP000756 | human VEGFB Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000810 | mouse Vegfb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000810 | mouse Vegfb Lentivirus particle |
Target information
| Target ID | GM-T30040 |
| Target Name | VEGFB |
| Gene ID | 7423,22340,89811,722115,476036,101092465,282121,100055238 |
| Gene Symbol and Synonyms | VEGF-B,VEGFB,VEGFL,VRF |
| Uniprot Accession | P49765,O35485,Q9XS49 |
| Uniprot Entry Name | VEGFB_HUMAN,VEGFB_RAT,VEGFB_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000173511 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: VEGFB, gene name: VEGFB, also named as VEGFL, VRF. This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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