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Anti-PLF4/ PF4/ CXCL4 functional antibody
Anti-PLF4/ PF4/ CXCL4 functional antibody for cell culture, ELISA & in-vivo assay
Go to PF4/PF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30827-Ab-1/ GM-Tg-hg-T30827-Ab-2 | Anti-Human PF4 monoclonal antibody | Human |
| GM-Tg-rg-T30827-Ab-1/ GM-Tg-rg-T30827-Ab-2 | Anti-Rat PF4 monoclonal antibody | Rat |
| GM-Tg-mg-T30827-Ab-1/ GM-Tg-mg-T30827-Ab-2 | Anti-Mouse PF4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T30827-Ab-1/ GM-Tg-cynog-T30827-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PF4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30827-Ab-1/ GM-Tg-felg-T30827-Ab-2 | Anti-Feline PF4 monoclonal antibody | Feline |
| GM-Tg-cang-T30827-Ab-1/ GM-Tg-cang-T30827-Ab-2 | Anti-Canine PF4 monoclonal antibody | Canine |
| GM-Tg-bovg-T30827-Ab-1/ GM-Tg-bovg-T30827-Ab-2 | Anti-Bovine PF4 monoclonal antibody | Bovine |
| GM-Tg-equg-T30827-Ab-1/ GM-Tg-equg-T30827-Ab-2 | Anti-Equine PF4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30827-Ab-1/ GM-Tg-hg-T30827-Ab-2; GM-Tg-rg-T30827-Ab-1/ GM-Tg-rg-T30827-Ab-2; GM-Tg-mg-T30827-Ab-1/ GM-Tg-mg-T30827-Ab-2; GM-Tg-cynog-T30827-Ab-1/ GM-Tg-cynog-T30827-Ab-2; GM-Tg-felg-T30827-Ab-1/ GM-Tg-felg-T30827-Ab-2; GM-Tg-cang-T30827-Ab-1/ GM-Tg-cang-T30827-Ab-2; GM-Tg-bovg-T30827-Ab-1/ GM-Tg-bovg-T30827-Ab-2; GM-Tg-equg-T30827-Ab-1/ GM-Tg-equg-T30827-Ab-2 |
| Products Name | Anti-PF4 monoclonal antibody |
| Format | mab |
| Target Name | PF4 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PF4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T30827-Ag-1 | Recombinant multi-species PLF4/ PF4/ CXCL4 protein |
| Cytokine | GM-Tg-g-T30827-Ag-1 | platelet factor 4 (PF4) protein |
| ORF Viral Vector | vGMLP004508 | human PF4 Lentivirus particle |
| ORF Viral Vector | pGMLP004508 | human PF4 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000559 | mouse Pf4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000559 | mouse Pf4 Lentivirus particle |
Target information
| Target ID | GM-T30827 |
| Target Name | PF4 |
| Gene ID | 5196,56744,360918,703451,507790,100630489 |
| Gene Symbol and Synonyms | CXCL4,LOC100630489,PF-4,PF4,Pf4a,RATPF4A,SCYB4 |
| Uniprot Accession | P02776,P06765,P02777 |
| Uniprot Entry Name | PLF4_HUMAN,PLF4_RAT,PLF4_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | cancer |
| Gene Ensembl | ENSG00000163737 |
| Target Classification | N/A |
The target: PF4, gene name: PF4, also named as CXCL4, PF-4, SCYB4. This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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