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Anti-5HT2B/ HTR2B/ 5-HT(2B) monoclonal antibody
Anti-5HT2B/ HTR2B/ 5-HT(2B) antibody for FACS & in-vivo assay
Go to HTR2B/HTR2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T31204-Ab-1/ GM-Tg-hg-T31204-Ab-2 | Anti-Human HTR2B monoclonal antibody | Human |
| GM-Tg-rg-T31204-Ab-1/ GM-Tg-rg-T31204-Ab-2 | Anti-Rat HTR2B monoclonal antibody | Rat |
| GM-Tg-mg-T31204-Ab-1/ GM-Tg-mg-T31204-Ab-2 | Anti-Mouse HTR2B monoclonal antibody | Mouse |
| GM-Tg-cynog-T31204-Ab-1/ GM-Tg-cynog-T31204-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTR2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T31204-Ab-1/ GM-Tg-felg-T31204-Ab-2 | Anti-Feline HTR2B monoclonal antibody | Feline |
| GM-Tg-cang-T31204-Ab-1/ GM-Tg-cang-T31204-Ab-2 | Anti-Canine HTR2B monoclonal antibody | Canine |
| GM-Tg-bovg-T31204-Ab-1/ GM-Tg-bovg-T31204-Ab-2 | Anti-Bovine HTR2B monoclonal antibody | Bovine |
| GM-Tg-equg-T31204-Ab-1/ GM-Tg-equg-T31204-Ab-2 | Anti-Equine HTR2B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T31204-Ab-1/ GM-Tg-hg-T31204-Ab-2; GM-Tg-rg-T31204-Ab-1/ GM-Tg-rg-T31204-Ab-2; GM-Tg-mg-T31204-Ab-1/ GM-Tg-mg-T31204-Ab-2; GM-Tg-cynog-T31204-Ab-1/ GM-Tg-cynog-T31204-Ab-2; GM-Tg-felg-T31204-Ab-1/ GM-Tg-felg-T31204-Ab-2; GM-Tg-cang-T31204-Ab-1/ GM-Tg-cang-T31204-Ab-2; GM-Tg-bovg-T31204-Ab-1/ GM-Tg-bovg-T31204-Ab-2; GM-Tg-equg-T31204-Ab-1/ GM-Tg-equg-T31204-Ab-2 |
| Products Name | Anti-HTR2B monoclonal antibody |
| Format | mab |
| Target Name | HTR2B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HTR2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species 5HT2B/ HTR2B/ 5-HT(2B) VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm004005 | mouse Htr2b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004005 | mouse Htr2b Lentivirus particle |
Target information
| Target ID | GM-T31204 |
| Target Name | HTR2B |
| Gene ID | 3357,15559,29581,711808,403881,101095762,407135,100057052 |
| Gene Symbol and Synonyms | 5-HT(2B),5-HT-2B,5-HT-2F,5-HT2B,5HT2B,5htr2b,HTR2B |
| Uniprot Accession | P41595,P30994 |
| Uniprot Entry Name | 5HT2B_HUMAN,5HT2B_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000135914 |
| Target Classification | GPCR |
The target: HTR2B, gene name: HTR2B, also named as 5-HT(2B), 5-HT-2B, 5-HT2B. This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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